Rosensweig N S, Herman R H
J Clin Invest. 1968 Oct;47(10):2253-62. doi: 10.1172/JCI105910.
The specific effect of dietary sugars on jejunal disaccharidase activity in seven normal nonfasted male volunteers was studied. The sugars tested were sucrose, maltose, lactose, glucose, fructose, and galactose. Comparisons were made of the effects of each sugar in an isocaloric liquid diet. In all subjects, sucrose feeding, as compared to glucose feeding, significantly increased jejunal sucrase (S) and maltase (M) activities, but not lactase (L) activity. The S/L and M/L ratios increased to a significant degree. Fructose feeding, in two subjects, gave results similar to sucrose when comparing fructose and glucose diets. One subject was fed lactose, galactose, and maltose. These sugars, compared to glucose, did not increase disaccharidase activity. Fructose appears to be the active principle in the sucrose molecule. These results demonstrate that specific dietary sugars can alter enzyme activity in the small intestine of man in a specific fashion. Sucrose and fructose are able to regulate sucrase and maltase activity. Dietary alteration of intestinal enzymes may represent a suitable system for studying the regulation of enzyme activity in man.
研究了七种正常非空腹男性志愿者饮食中的糖类对空肠双糖酶活性的具体影响。所测试的糖类有蔗糖、麦芽糖、乳糖、葡萄糖、果糖和半乳糖。在等热量液体饮食中比较了每种糖类的作用。在所有受试者中，与给予葡萄糖相比，给予蔗糖显著增加了空肠蔗糖酶（S）和麦芽糖酶（M）的活性，但未增加乳糖酶（L）的活性。S/L和M/L比值显著升高。在两名受试者中，比较果糖饮食和葡萄糖饮食时，给予果糖的结果与蔗糖相似。一名受试者摄入了乳糖、半乳糖和麦芽糖。与葡萄糖相比，这些糖类并未增加双糖酶活性。果糖似乎是蔗糖分子中的活性成分。这些结果表明，特定的饮食糖类能够以特定方式改变人体小肠中的酶活性。蔗糖和果糖能够调节蔗糖酶和麦芽糖酶的活性。肠道酶的饮食改变可能是研究人体酶活性调节的合适系统。
