Filip C C, Allen J S, Gustafson R A, Allen R G, Walker J R
J Bacteriol. 1974 Aug;119(2):443-9. doi: 10.1128/jb.119.2.443-449.1974.
The dnaH locus is the fourth gene to be identified as required for deoxyribonucleic acid polymerization in Escherichia coli. A temperature-sensitive mutant defective in this gene exhibited an abrupt decrease in rate of deoxyribonucleic acid synthesis when shifted to 42 C. The locus mapped in the proC-purE region of the chromosome by conjugation and was co-transducible with purE. dnaH(+) is carried on the F'(13) episome and is dominant over the dnaH(-) mutation.
dnaH基因座是被确定为大肠杆菌中脱氧核糖核酸聚合所必需的第四个基因。该基因缺陷的温度敏感型突变体在转移到42℃时，脱氧核糖核酸合成速率会突然下降。通过接合作用，该基因座定位于染色体的proC-purE区域，并与purE共转导。dnaH(+) 存在于F'(13) 附加体上，对dnaH(-) 突变具有显性作用。
