BALB-c小鼠中产生IgM的肿瘤：B细胞成熟的模型
IgM-producing tumors in the BALB-c mouse: a model for B-cell maturation.
作者信息
Andersson J, Buxbaum J, Citronbaum R, Douglas S, Forni L, Melchers F, Pernis B, Stott D
出版信息
J Exp Med. 1974 Sep 1;140(3):742-63. doi: 10.1084/jem.140.3.742.
Abstract
Five adjuvant induced BALB/c tumors producing IgM-McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781-were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10-25-h stimulated normal B cells, 3469 cells resemble 20-35-h stimulated B cells, TEPC 183 cells resemble 45-65-h stimulated B cells, Y 5781 cells resemble 80-110-h stimulated B cells, and McPc 774 cells resemble 100-130-h stimulated B cells.
摘要
对五种佐剂诱导的BALB/c肿瘤进行了研究，这些肿瘤产生IgM-McPc 1748、W 3469、TEPC 183、McPc 774和Y 5781。通过电子显微镜进行形态学特征分析，利用免疫荧光分析表面结合和胞质内IgM的分布，并对IgM的合成、周转和分泌进行生化研究。与正常的、脂多糖刺激的B细胞相比，不同肿瘤的细胞似乎代表了B细胞成熟的不同阶段。因此，McPc 1748肿瘤细胞类似于刺激10-25小时的正常B细胞，3469细胞类似于刺激20-35小时的B细胞，TEPC 183细胞类似于刺激45-65小时的B细胞，Y 5781细胞类似于刺激80-110小时的B细胞，McPc 774细胞类似于刺激100-130小时的B细胞。
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