免疫球蛋白M碳水化合物部分的生物合成
Biosynthesis of the carbohydrate portions of immunoglobulin M.
作者信息
Parkhouse R M, Melchers F
出版信息
Biochem J. 1971 Nov;125(1):235-40. doi: 10.1042/bj1250235.
Abstract
Incorporations of radioactive mannose, galactose and fucose into MOPC 104E mouse plasma-cell tumour suspensions suggest a stepwise addition of carbohydrate residues to immunoglobulin M (IgM) during the process of secretion. Mannose and glucosamine residues are added at an early stage, whereas galactose and fucose are added just before, or at the time that, IgM leaves the cell. Free light chains secreted in excess by the same tumour cells incubated with mannose, galactose or fucose contained barely detectable amounts of radioactivity.
摘要
将放射性甘露糖、半乳糖和岩藻糖掺入MOPC 104E小鼠浆细胞瘤悬液表明，在分泌过程中碳水化合物残基逐步添加到免疫球蛋白M（IgM）上。甘露糖和氨基葡萄糖残基在早期添加，而半乳糖和岩藻糖在IgM离开细胞之前或之时添加。用甘露糖、半乳糖或岩藻糖孵育的同一肿瘤细胞分泌的过量游离轻链几乎检测不到放射性。
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Macroglobulin-Producing Plasma-Cell Tumor in Mice: Identification of a New Light Chain.巨球蛋白血症浆细胞瘤小鼠模型：一种新的轻链的鉴定。
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A study of the carbohydrate present in three type K macroglobulins.对三种K型巨球蛋白中所含碳水化合物的研究。
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The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12.腺病毒的多肽。I. 病毒体中多种蛋白质成分的证据以及2型、7A 型和12型的比较
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