Sissons J G, Evans D J, Peters D K, Eisinger A J, Boulton-Jones J M, Simpson I J, Macanovic M
Br Med J. 1974 Oct 5;4(5935):11-4. doi: 10.1136/bmj.4.5935.11.
Glomerulonephritis associated with antibody to glomerular basement membrane, shown by linear staining of the glomerular basement membrane with fluoresceinated anti-IgG antisera, was found in only 10 out of 400 (2.5%) renal biopsy specimens studied by immunofluorescence. Seven of these cases had rapidly progressive glomerulonephritis, five with lung haemorrhage (Goodpasture's syndrome) and two without, and three had less severe nephritis without lung haemorrhage. Circulating antibody to glomerular basement membrane, measured by a passive haemagglutination technique and by indirect immunofluorescence, was detected in the serum of all patients with rapidly progressive glomerulonephritis by both techniques but only by the passive haemagglutination method in two of the other three patients. Two patients died of their lung haemorrhage, one despite bilateral nephrectomy, and lung haemorrhage and circulating antibody to glomerular basement membrane persisted after bilateral nephrectomy in another patient.
通过用荧光素标记的抗IgG抗血清对肾小球基底膜进行线性染色显示，与肾小球基底膜抗体相关的肾小球肾炎在400例经免疫荧光研究的肾活检标本中仅发现10例（2.5%）。其中7例患有快速进行性肾小球肾炎，5例伴有肺出血（Goodpasture综合征），2例无肺出血，3例患有较轻的无肺出血的肾炎。通过被动血凝技术和间接免疫荧光法检测的循环肾小球基底膜抗体，在所有快速进行性肾小球肾炎患者的血清中均通过这两种技术检测到，但在另外3例患者中的2例中仅通过被动血凝法检测到。2例患者死于肺出血，1例尽管进行了双侧肾切除术仍死亡，另1例患者在双侧肾切除术后肺出血和循环肾小球基底膜抗体持续存在。
