Savage C O, Pusey C D, Bowman C, Rees A J, Lockwood C M
Br Med J (Clin Res Ed). 1986 Feb 1;292(6516):301-4. doi: 10.1136/bmj.292.6516.301.
Clinical and pathological data on 71 patients from throughout the British Isles who developed antiglomerular basement membrane antibody mediated nephritis in the period 1980-4 were studied. Two principle patterns of disease were recognised: young men presenting in their 20s with Goodpasture's syndrome (glomerulonephritis and lung haemorrhage) and women presenting in their 60s with glomerulonephritis alone. The effect of treatment on prognosis of a total of 108 patients was also reviewed (the 71 patients plus patients seen before 1980 at Hammersmith Hospital). Treatment with prednisolone, cytotoxic drugs, and plasma exchange hastened the time to clearance of autoantibody and improved the outlook of patients who were not dependent on dialysis and those with lung haemorrhage.
对1980年至1984年间在英伦诸岛各地出现抗肾小球基底膜抗体介导性肾炎的71例患者的临床和病理数据进行了研究。识别出两种主要疾病模式：20多岁出现肺出血肾炎综合征（肾小球肾炎和肺出血）的年轻男性，以及60多岁仅出现肾小球肾炎的女性。还回顾了总共108例患者（71例患者加上1980年前在哈默史密斯医院就诊的患者）的治疗对预后的影响。泼尼松龙、细胞毒性药物和血浆置换治疗加快了自身抗体清除的时间，并改善了不依赖透析患者和有肺出血患者的预后。
