Seaton A, Meland J M, Lapp N L
Thorax. 1971 Nov;26(6):683-8. doi: 10.1136/thx.26.6.683.
Two patients with Goodpasture's syndrome are reported. One showed an apparently spontaneous remission and has survived in good health for over five years since the onset of his illness; he was treated for part of this time with steroids and chlorambucil. The second patient failed to respond to steroids but appeared to improve rapidly from a moribund state on administration of azathioprine; he remains well, although in mild renal failure, over a year later. The management of 35 other patients reported to have survived this illness is reviewed. It appears that both the renal and pulmonary features of Goodpasture's syndrome may undergo spontaneous remission, and that the latter can sometimes be suppressed with steroid or immunosuppressant therapy. On four occasions the pulmonary manifestations of the disease have been arrested by nephrectomy.
报告了两名患有肺出血肾炎综合征的患者。其中一名患者表现出明显的自发缓解，自发病以来健康存活超过五年；在此期间的部分时间他接受了类固醇和苯丁酸氮芥治疗。第二名患者对类固醇治疗无反应，但在使用硫唑嘌呤后似乎从濒死状态迅速好转；一年多后，他虽然仍有轻度肾衰竭，但情况良好。对报告存活的其他35名患者的治疗情况进行了回顾。似乎肺出血肾炎综合征的肾脏和肺部特征都可能自发缓解，而且后者有时可用类固醇或免疫抑制疗法抑制。有四次通过肾切除术阻止了该疾病的肺部表现。
