氟比洛芬与保泰松治疗强直性脊柱炎的双盲交叉试验
Double-bind cross-over tiral of flurbiprofen and phenylbutazone in ankylosing spondylitis.
作者信息
Calin A, Grahame R
出版信息
Br Med J. 1974 Nov 30;4(5943):496-9. doi: 10.1136/bmj.4.5943.496.
Abstract
A double-blind cross-over study in 35 patients with ankylosing spondylitis was carried out comparing flurbiprofen (150 mg daily)-a new non-steroidal anti-inflammatory agent-with phenylbutazone (300 mg daily) over a four-week period. Flurbiprofen was well tolerated and shown to have therapeutic efficacy approaching that of phenylbutazone. The results suggest that flurbiprofen may prove a valuable alternative in the treatment of ankylosing spondylitis, and longterm efficacy and tolerance studies are clearly indicated.
摘要
对35例强直性脊柱炎患者进行了一项双盲交叉研究，在四周的时间内，将新型非甾体抗炎药氟比洛芬（每日150毫克）与保泰松（每日300毫克）进行比较。氟比洛芬耐受性良好，且显示出与保泰松相近的治疗效果。结果表明，氟比洛芬可能被证明是治疗强直性脊柱炎的一种有价值的替代药物，显然需要进行长期疗效和耐受性研究。
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