Busch S, Kern F, Schulz V
Prax Klin Pneumol. 1979 Apr;33 Suppl 1:651-4.
Investigations during the past years have established that determinations of closing volume, flow-volume curves and frequency-dependent compliance are capable of detecting pathological changes in the bronchial system at a time when the customary lung function tests (FEV1.0 resistance as measured by bodyplethysmography) are still normal. These observations have been made use of to diagnose incipient damage in persons exposed to bronchial noxae. In the present investigation the effect of smoking on the airways was studied in a group of 25 persons aged 20-25 years by determining the closing volume and differences in ventilatory distribution (Thews method). The results were compared with those obtained in a group of 27 non-smokers in the same age group.
过去几年的研究已经证实，在常规肺功能测试（通过体容积描记法测量的FEV1.0阻力）仍正常时，闭合气量、流量-容积曲线和频率依赖性顺应性的测定能够检测出支气管系统的病理变化。这些观察结果已被用于诊断接触支气管有害物质的人群中的早期损伤。在本研究中，通过测定闭合气量和通气分布差异（修斯方法），对一组25名年龄在20至25岁之间的人进行了吸烟对气道影响的研究。并将结果与同年龄组的27名非吸烟者的结果进行了比较。
