Yourassowsky E, Vanderlinden M P, Schoutens E
J Clin Pathol. 1974 Nov;27(11):897-901. doi: 10.1136/jcp.27.11.897.
When tested on Wellcotest (sensitivity test agar, Wellcome) supplemented with lysed horse blood, 59 clinical isolates of beta-haemolytic streptococci, belonging to several serological groups, are all sensitive to sulphamethoxazole, to trimethoprim, and to cotrimoxazole. The results obtained on diagnostic sensitivity test agar (Oxoid) containing lysed horse blood are comparable. When Mueller Hinton agar (Difco) is used, some of these strains are called resistant: this is especially true in the case of sulphamethoxazole.Furthermore, on Mueller Hinton agar, even supplemented with lysed blood, discrepancies between diameters of inhibition zone and MIC values exist for the three drugs tested, strains with a low MIC being considered resistant by the disc method. Such disagreements are not observed with non-streptococcal control strains.
在用添加了裂解马血的Wellcotest（敏感性测试琼脂，惠康公司）进行测试时，59株属于几个血清学组的β溶血性链球菌临床分离株对磺胺甲恶唑、甲氧苄啶和复方新诺明均敏感。在含有裂解马血的诊断敏感性测试琼脂（Oxoid公司）上获得的结果相当。当使用穆勒-欣顿琼脂（Difco公司）时，其中一些菌株被判定为耐药：磺胺甲恶唑的情况尤其如此。此外，在穆勒-欣顿琼脂上，即使添加了裂解血，所测试的三种药物的抑菌圈直径和最低抑菌浓度值之间也存在差异，低最低抑菌浓度的菌株通过纸片法被判定为耐药。非链球菌对照菌株未观察到此类差异。
