Garcia Leme J, Lico M
Br J Pharmacol. 1974 Aug;51(4):491-6. doi: 10.1111/j.1476-5381.1974.tb09666.x.
1 The amplitudes of the first positive and the first negative waves of cortical potentials evoked by electrical stimulation of the dental pulp in the rat were decreased following electrical stimulation of the peripheral cut end of the saphenous nerve.2 This effect was greatly diminished when the stimulation of the saphenous nerve was performed with the saphenous or femoral veins ligated.3 During stimulation of the saphenous nerve of a donor rat, the subcutaneous tissue in the area supplied by the nerve was perfused; when the perfusate (in which a permeability-increasing factor was detected) was injected intravenously into a recipient animal, a decrease in the amplitude of the evoked cortical potential of the recipient rat was also observed.4 Intravenous injections of 5-hydroxytryptamine, histamine, bradykinin, prostaglandins or adenosine-triphosphate produced no effect on the evoked cortical potential, whereas large doses of acetylsalicylic acid caused a decrease.5 It is suggested that a humoral factor, released during sensory nerve stimulation, may help to modulate the processing of afferent inputs from pain receptors.
电刺激大鼠牙髓诱发的皮质电位的第一个正向波和第一个负向波的波幅，在电刺激隐神经外周切断端后降低。
当结扎隐静脉或股静脉后再刺激隐神经时，这种效应大大减弱。
在刺激供体大鼠的隐神经期间，对神经所支配区域的皮下组织进行灌注；当将灌注液（检测到其中有一种通透性增加因子）静脉注射到受体动物体内时，也观察到受体大鼠诱发皮质电位的波幅降低。
静脉注射5-羟色胺、组胺、缓激肽、前列腺素或三磷酸腺苷对诱发皮质电位无影响，而大剂量乙酰水杨酸则导致波幅降低。
提示在感觉神经刺激期间释放的一种体液因子可能有助于调节来自痛觉感受器的传入输入的处理过程。
