Reynolds D V
Science. 1969 Apr 25;164(3878):444-5. doi: 10.1126/science.164.3878.444.
Chronic monopolar electrodes were implanted in the region of the midbrain central gray in eight rats. In three rats, continuous 60 cycle-per-second sine-wave stimulation resulted in an electrical analgesia defined by the elimination of responses to aversive stimulation while general motor responsiveness was retained. Exploratory laparotomy was carried out in these animals during continuous brain stimulation without the use of chemical anesthetics. Following surgery, brain stimulation was terminated, and responses to aversive stimuli returned. Electrodes effective in inducing electrical analgesia at the lowest currents were located at the dorsolateral perimeter of the midbrain central gray. It was concluded that focal brain stimulation in this region can induce analgesia in the absence of diffusely applied "whole brain" stimulation.
在八只大鼠的中脑中央灰质区域植入了慢性单极电极。在三只大鼠中，持续的60赫兹正弦波刺激产生了一种电镇痛效应，其表现为对厌恶性刺激的反应消失而一般运动反应性得以保留来定义。在持续脑刺激期间，对这些动物进行了剖腹探查术，未使用化学麻醉剂。手术后，终止脑刺激，对厌恶性刺激的反应恢复。在最低电流下能有效诱导电镇痛的电极位于中脑中央灰质的背外侧周边。得出的结论是，在该区域进行局灶性脑刺激可以在不进行广泛应用的“全脑”刺激的情况下诱导镇痛。
