C3 片段对 C3 依赖性玫瑰花结形成及抗原诱导的淋巴细胞转化的抑制作用。
Inhibition by C3 fragments of C3-dependent rosette formation and antigen-induced lymphocyte transformation.
作者信息
Pepys M B, Butterworth A E
出版信息
Clin Exp Immunol. 1974 Oct;18(2):273-82.
Abstract
The interaction between human lymphocytes and fixed C3 was inhibited by fluid phase C3b and C3c prepared by trypsinization of purified human C3. These C3 fragments suppressed transformation of human lymphocytes by specific antigens, PPD and somatic antigen, but not by phytohaemagglutinin, a non-specific mitogen. These observations indicate the form of C3 which interacts with complement receptor lymphocytes and suggest that this interaction may play a part in lymphocyte activation by antigen.
摘要
通过对纯化的人C3进行胰蛋白酶消化制备的液相C3b和C3c可抑制人淋巴细胞与固定C3之间的相互作用。这些C3片段可抑制人淋巴细胞被特异性抗原、结核菌素纯蛋白衍生物（PPD）和菌体抗原转化，但不能抑制被植物血凝素（一种非特异性促细胞分裂剂）转化。这些观察结果表明了与补体受体淋巴细胞相互作用的C3形式，并提示这种相互作用可能在抗原激活淋巴细胞过程中发挥作用。
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