用有丝分裂原或抗原刺激后人淋巴母细胞上的B细胞和T细胞标志物。
B- and T-cell markers on human lymphoblasts after stimulation with mitogen or antigens.
作者信息
Kreeftenberg J G, Leerling M F, Loggen H G
出版信息
Clin Exp Immunol. 1975 Oct;22(1):121-5.
Abstract
Receptors for sheep erythrocytes and for the third component of complement were demonstrated on human lymphoblasts after stimulation with various antigens and mitogens. With these markers B- and T-cell stimulation could be differentiated. Phytohaemagglutinin (PHA) and purified protein derivative (PPD) proved to activate predominantly T cells, whereas foetal calf serum (FCS) was shown to be a B-cell stimulator. Candida albicans and allogeneic cells, on the other hand, stimulated both B and T cells.
摘要
在用各种抗原和有丝分裂原刺激后，在人淋巴母细胞上证实了绵羊红细胞和补体第三成分的受体。利用这些标志物可以区分B细胞和T细胞的刺激情况。植物血凝素（PHA）和纯化蛋白衍生物（PPD）被证明主要激活T细胞，而胎牛血清（FCS）被证明是一种B细胞刺激剂。另一方面，白色念珠菌和同种异体细胞则刺激B细胞和T细胞。
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本文引用的文献
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Lymphocyte transformation in vitro. I. Tissue culture conditions and quantitative measurements.体外淋巴细胞转化。I. 组织培养条件及定量测定
Clin Exp Immunol. 1968 Jul;3(6):571-84.
2
Factors influencing the stimulation of human lymphocytes by antigen during culture in vitro. Conditions for lymphocyte stimulation.体外培养期间影响抗原对人淋巴细胞刺激作用的因素。淋巴细胞刺激的条件。
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A technique for quantitative measurement of endotoxin in human plasma.一种定量测量人血浆中内毒素的技术。
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Binding of sheep red blood cells to a large population of human lymphocytes.绵羊红细胞与大量人类淋巴细胞的结合。
Nature. 1971 Apr 23;230(5295):531-2. doi: 10.1038/230531a0.
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Modulation of lymphocytic responses by factors in human plasma. I. The effects on normal, stimulated lymphocytes of various normal plasmas in microplate culture.人血浆中因子对淋巴细胞反应的调节。I. 微孔板培养中各种正常人血浆对正常刺激淋巴细胞的影响。
Int Arch Allergy Appl Immunol. 1974;46(4):584-99. doi: 10.1159/000231159.
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Lymphocyte activation. V. Quantitation of the proliferative responses to mitogens using defined T and B cell populations.淋巴细胞激活。V. 使用特定的T细胞和B细胞群体对有丝分裂原的增殖反应进行定量分析。
Clin Exp Immunol. 1973 Aug;14(4):581-96.
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J Clin Invest. 1972 Aug;51(8):1933-8. doi: 10.1172/JCI106999.
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