牛传染性阴道炎：感染期间细菌的抗原变异
Bovine veneral vibriosis: antigenic variation of the bacterium during infection.
作者信息
Corbeil L B, Schurig G G, Bier P J, Winter A J
出版信息
Infect Immun. 1975 Feb;11(2):240-4. doi: 10.1128/iai.11.2.240-244.1975.
Abstract
Host parasite relationships in the female genital tract were studied in bovine venereal vibriosis by investigating agglutinin production and alterations in superficial antigens of the bacterium during the course of infection in two heifers. Cervicovaginal mucus (CVM) steamed cell agglutinins were shown to appear earlier and remain at consistently higher levels than whole-cell agglutinins. Whole-cell agglutinin titers fluctuated much more than steamed cell titers, suggesting possible changes in whole-cell antigens. Marked antigenic variation was demonstrated in successive monthly CVM isolates from the two heifers by agglutination tests with rabbit antisera of various specificities. Some changes in CVM antibody specificity during the infection were noted also. Antigenic variation in the bacterium was proposed as a mechanism for maintenance of the asymptomatic cervicovaginal carrier state in the presence of antibody.
摘要
通过研究两头小母牛感染过程中细菌凝集素的产生以及表面抗原的变化，对牛性病弧菌感染时雌性生殖道中的宿主-寄生虫关系进行了研究。结果显示，宫颈阴道黏液（CVM）热灭活细胞凝集素比全细胞凝集素出现得更早，且水平持续更高。全细胞凝集素滴度的波动比热灭活细胞滴度大得多，这表明全细胞抗原可能发生了变化。通过用具有不同特异性的兔抗血清进行凝集试验，在从这两头小母牛连续每月采集的CVM分离物中证实了明显的抗原变异。在感染过程中还注意到CVM抗体特异性的一些变化。细菌的抗原变异被认为是在存在抗体的情况下维持无症状宫颈阴道携带状态的一种机制。
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