血清和钙对庆大霉素及羧苄西林对铜绿假单胞菌杀菌活性的影响
Influence of serum and calcium on the bactericidal activity of gentamicin and carbenicillin on Pseudomonas aeruginosa.
作者信息
Davis S D, Iannetta A
出版信息
Appl Microbiol. 1972 Apr;23(4):775-9. doi: 10.1128/am.23.4.775-779.1972.
Abstract
Because calcium was found to be antagonistic in vitro to the activity of colistin and polymyxin B on Pseudomonas aeruginosa, the effects of calcium and serum on gentamicin and carbenicillin were also examined. Serum was antagonistic to gentamicin in antibiotic tube dilution tests on five strains of P. aeruginosa. Serum was not antagonistic to carbenicillin in tube dilution tests. Physiologic concentrations of calcium antagonized the activity of gentamicin but not carbenicillin. The antagonism observed with gentamicin was less than that previously seen with colistin. The antagonistic effect of calcium and serum was removed by a chelating agent. Gentamicin and carbenicillin may be more active in vivo against P. aeruginosa than colistin or polymyxin B.
摘要
由于发现钙在体外对黏菌素和多黏菌素B针对铜绿假单胞菌的活性具有拮抗作用，因此还研究了钙和血清对庆大霉素和羧苄西林的影响。在对五株铜绿假单胞菌进行的抗生素试管稀释试验中，血清对庆大霉素具有拮抗作用。在试管稀释试验中，血清对羧苄西林无拮抗作用。生理浓度的钙可拮抗庆大霉素的活性，但不拮抗羧苄西林的活性。观察到的庆大霉素拮抗作用小于先前观察到的黏菌素的拮抗作用。钙和血清的拮抗作用可被螯合剂消除。庆大霉素和羧苄西林在体内对铜绿假单胞菌的活性可能比黏菌素或多黏菌素B更强。
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