血清和钙对庆大霉素及羧苄西林对铜绿假单胞菌杀菌活性的影响
Influence of serum and calcium on the bactericidal activity of gentamicin and carbenicillin on Pseudomonas aeruginosa.
作者信息
Davis S D, Iannetta A
出版信息
Appl Microbiol. 1972 Apr;23(4):775-9. doi: 10.1128/am.23.4.775-779.1972.
Abstract
Because calcium was found to be antagonistic in vitro to the activity of colistin and polymyxin B on Pseudomonas aeruginosa, the effects of calcium and serum on gentamicin and carbenicillin were also examined. Serum was antagonistic to gentamicin in antibiotic tube dilution tests on five strains of P. aeruginosa. Serum was not antagonistic to carbenicillin in tube dilution tests. Physiologic concentrations of calcium antagonized the activity of gentamicin but not carbenicillin. The antagonism observed with gentamicin was less than that previously seen with colistin. The antagonistic effect of calcium and serum was removed by a chelating agent. Gentamicin and carbenicillin may be more active in vivo against P. aeruginosa than colistin or polymyxin B.
摘要
由于发现钙在体外对黏菌素和多黏菌素B针对铜绿假单胞菌的活性具有拮抗作用，因此还研究了钙和血清对庆大霉素和羧苄西林的影响。在对五株铜绿假单胞菌进行的抗生素试管稀释试验中，血清对庆大霉素具有拮抗作用。在试管稀释试验中，血清对羧苄西林无拮抗作用。生理浓度的钙可拮抗庆大霉素的活性，但不拮抗羧苄西林的活性。观察到的庆大霉素拮抗作用小于先前观察到的黏菌素的拮抗作用。钙和血清的拮抗作用可被螯合剂消除。庆大霉素和羧苄西林在体内对铜绿假单胞菌的活性可能比黏菌素或多黏菌素B更强。
相似文献
1
Influence of serum and calcium on the bactericidal activity of gentamicin and carbenicillin on Pseudomonas aeruginosa.
Appl Microbiol. 1972 Apr;23(4):775-9. doi: 10.1128/am.23.4.775-779.1972.
2
3
[The antimicrobial action of blood serum following simultaneous application of gentamicin and carbenicillin].
Zentralbl Bakteriol Orig. 1971;216(3):345-9.
4
In vitro effects of carbenicillin combined with gentamicin or polymyxin B against Pseudomonas aeruginosa.
Appl Microbiol. 1969 Sep;18(3):469-73. doi: 10.1128/am.18.3.469-473.1969.
5
Susceptibility of recent isolates of Pseudomonas aeruginosa to gentamicin, polymyxin, and five penicillins, with observations on the pyocin and immunotypes of the strains.
Appl Microbiol. 1971 Nov;22(5):870-5. doi: 10.1128/am.22.5.870-875.1971.
6
Relative antagonism in vitro of calcium in serum to the bactericidal activities of gentamicin and tobramycin on Pseudomonas aeruginosa.
Chemotherapy. 1973 Oct;19(4):243-53. doi: 10.1159/000221461.
7
Activity of aminoglycoside antibiotics aganst Pseudomonas aeruginosa: specificity and site of calcium and magnesium antagonism.
J Infect Dis. 1973 Jun;127(6):663-9. doi: 10.1093/infdis/127.6.663.
8
Susceptibility of 1,500 isolates of Pseudomonas aeruginosa to gentamicin, carbenicillin, colistin, and polymyxin B.
Antimicrob Agents Chemother. 1974 Jan;5(1):9-15. doi: 10.1128/AAC.5.1.9.
9
Comparative in vitro activity of tobramycin, gentamicin, kanamycin, colistin, carbenicillin, and ticarcillin and clinical isolates of Pseudomonas aeruginosa: epidemiological and therapeutic implications.
J Infect Dis. 1976 Aug;134 Suppl:S50-6. doi: 10.1093/infdis/134.supplement_1.s50.
10
In vitro susceptibility of Pseudomonas aeruginosa to carbenicillin and the combination of carbenicillin and gentamicin.
Appl Microbiol. 1969 Sep;18(3):303-6. doi: 10.1128/am.18.3.303-306.1969.
引用本文的文献
1
Bactericidal activity of gentamicin against Enterococcus faecalis in vitro and in vivo.
Antimicrob Agents Chemother. 2000 Aug;44(8):2077-80. doi: 10.1128/AAC.44.8.2077-2080.2000.
2
Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin.
Antimicrob Agents Chemother. 1973 Jan;3(1):24-8. doi: 10.1128/AAC.3.1.24.
3
Serum protein binding of the aminoglycoside antibiotics.
Antimicrob Agents Chemother. 1972 Sep;2(3):214-6. doi: 10.1128/AAC.2.3.214.
4
Antagonistic effect of calcium in serum on the activity of tobramycin against Pseudomonas.
Antimicrob Agents Chemother. 1972 Jun;1(6):466-9. doi: 10.1128/AAC.1.6.466.
5
Dissociation between results of in vitro and in vivo antibiotic susceptibility tests for some strains of Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 1974 Mar;5(3):281-8. doi: 10.1128/AAC.5.3.281.
6
Potentiation of susceptibility to aminoglycosides by salicylate in Escherichia coli.
Antimicrob Agents Chemother. 1990 May;34(5):786-91. doi: 10.1128/AAC.34.5.786.
7
Chemically defined antimicrobial susceptibility test medium for Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 1977 Mar;11(3):415-9. doi: 10.1128/AAC.11.3.415.
8
Effect of calcium and magnesium ions on the susceptibility of Pseudomonas species to tetracycline, gentamicin polymyxin B, and carbenicillin.
Antimicrob Agents Chemother. 1975 May;7(5):596-600. doi: 10.1128/AAC.7.5.596.
9
Effect of divalent cation concentrations on the antibiotic susceptibilities of nonfermenters other than Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 1979 Oct;16(4):434-8. doi: 10.1128/AAC.16.4.434.
本文引用的文献
1
Role of Multivalent Cations in the Organization, Structure, and Assembly of the Cell Wall of Pseudomonas aeruginosa.
J Bacteriol. 1966 Aug;92(2):380-7. doi: 10.1128/jb.92.2.380-387.1966.
2
LABORATORY STUDIES ON GENTAMICIN.
Antimicrob Agents Chemother (Bethesda). 1963;161:153-6.
3
The problem of synergism and antagonism of combined drugs.
Arzneimittelforschung. 1953 Jun;3(6):285-90.
4
New semi-synthetic penicillin active against Pseudomonas pyocyanea.
Nature. 1967 Jul 1;215(5096):25-30. doi: 10.1038/215025a0.
5
Paradoxical synergism and antagonism between serum and the antibacterial activity of colistin.
J Infect Dis. 1971 Apr;123(4):392-8. doi: 10.1093/infdis/123.4.392.
6
Effect of ethylenediamine tetraacetate on the germicidal action of disinfectants against "Pseudomonas aeruginosa".
Acta Clin Belg. 1969;24(1):32-41. doi: 10.1080/17843286.1969.11716699.
7
Combined action of carbenicillin and gentamicin on Pseudomonas aeruginosa in vitro.
Appl Microbiol. 1969 Jun;17(6):893-6. doi: 10.1128/am.17.6.893-896.1969.
8
Loss of sensitivity to EDTA by Pseudomonas aeruginosa grown under conditions of Mg-limitation.
J Gen Microbiol. 1968 Dec;54(3):439-44. doi: 10.1099/00221287-54-3-439.
9
Carbenicillin and gentamycin in antibiotic combinations in vitro.
Chemotherapy. 1969;14(6):371-83. doi: 10.1159/000220646.
10
Carbenicillin: activity in vitro and absorption and excretion in normal young men.
Appl Microbiol. 1968 Nov;16(11):1753-60. doi: 10.1128/am.16.11.1753-1760.1968.
Zotero 插件