用重症肌无力患者血清进行抗球蛋白消耗试验。
Antiglobulin consumption test with sera from patients with myasthenia gravis.
作者信息
Aarli J A, Tönder O
出版信息
Clin Exp Immunol. 1970 Jul;7(1):11-21.
The antiglobulin consumption test was performed with sera from patients with myasthenia gravis, lyophilized skeletal muscle tissue serving as antigen. Incubation of the saline-treated tissue preparation with the antiglobulin serum resulted in a small titre reduction of antiglobulin, indicating binding of γ-globulins to the tissue (basal consumption). Treatment of the tissue with normal human serum resulted in a greater consumption. This was mediated by γG-globulins, normally present in human sera and with the capacity of binding to skeletal muscle (normal consumption). Sera from twenty-four patients with myasthenia gravis were tested in the antiglobulin consumption test. A positive reaction (pathological consumption) was observed in twelve (50%). Cross-reactions with cardiac muscle and thymus were demonstrated.
用重症肌无力患者的血清进行抗球蛋白消耗试验，冻干的骨骼肌组织作为抗原。用抗球蛋白血清孵育经生理盐水处理的组织制剂，导致抗球蛋白效价略有降低，表明γ球蛋白与组织结合（基础消耗）。用人正常血清处理组织会导致更大的消耗。这是由通常存在于人类血清中且具有与骨骼肌结合能力的γG球蛋白介导的（正常消耗）。对24例重症肌无力患者的血清进行了抗球蛋白消耗试验。12例（50%）观察到阳性反应（病理性消耗）。证明了与心肌和胸腺的交叉反应。
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