来自不同个体的淀粉样蛋白制剂之间的个体抗原特异性和交叉反应。

Clin Exp Immunol. 1972 Apr;10(4):635-47.

Amyloid fibrils were isolated from eleven amyloid-laden organs of six patients. By alkaline degradation, soluble units were obtained which gave antibody formation in rabbits. Gel precipitation and haemagglutination inhibition were used to characterize antigens of the amyloid. Evidence was obtained that amyloids from different organs of the same individual were identical in the antigenicity. In contrast, amyloids from different individuals each showed unique individual specificity. Besides this, antigenic cross-reactions were noted between the amyloid preparations. Finally, evidence for antigenic cross-reactivity between certain amyloid preparations and immunoglobulin light chains was obtained.

从6例患者的11个富含淀粉样蛋白的器官中分离出淀粉样纤维。通过碱性降解获得了可溶单元，这些单元能使兔子产生抗体形成。采用凝胶沉淀和血凝抑制法对淀粉样蛋白的抗原进行表征。有证据表明，同一个体不同器官的淀粉样蛋白在抗原性上是相同的。相比之下，来自不同个体的淀粉样蛋白各自表现出独特的个体特异性。除此之外，还注意到淀粉样蛋白制剂之间存在抗原交叉反应。最后，获得了某些淀粉样蛋白制剂与免疫球蛋白轻链之间抗原交叉反应的证据。