自身免疫性小鼠甲状腺炎。V. BSVS和BRVR小鼠中疾病的遗传影响。
Autoimmune murine thyroiditis. V. Genetic influence on the disease in BSVS and BRVR mice.
作者信息
Rose N R, Vladutiu A O, David C S, Shreffler D C
出版信息
Clin Exp Immunol. 1973 Oct;15(2):281-7.
Abstract
Two inbred strains of mice, BSVS and BRVR, are similar in their antibody response to thyroglobulin but differ significantly with respect to thyroid gland damage. F hybrids, like BSVS mice, respond well to thyroglobulin, exhibiting extensive thyroid lesions, whereas BRVR mice show minimal thyroid damage. -2 typing of the two strains showed that BSVS mice have a type similar to -2, with the -2D-end of -2 and the -2K-end of -2, whereas BRVR mice are -2. The cellular response to thyroglobulin appears to be influenced by a specific immune response gene located near the K-end of the -2 complex.
摘要
两种近交系小鼠，BSVS和BRVR，在对甲状腺球蛋白的抗体反应方面相似，但在甲状腺损伤方面有显著差异。F杂种小鼠，与BSVS小鼠一样，对甲状腺球蛋白反应良好，表现出广泛的甲状腺病变，而BRVR小鼠的甲状腺损伤最小。对这两个品系的-2分型显示，BSVS小鼠具有类似于-2的类型，带有-2的-2D端和-2的-2K端，而BRVR小鼠是-2。对甲状腺球蛋白的细胞反应似乎受位于-2复合体K端附近的一个特异性免疫反应基因的影响。
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