Tomita I, Sano M, Serizawa S, Ohta K, Katou M
Stroke. 1979 May-Jun;10(3):323-6. doi: 10.1161/01.str.10.3.323.
The levels of lipid peroxides, determined as thiobarbituric acid reactive substances (TBARS), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were examined in the blood from stroke-prone spontaneously hypertensive rats (SHRSP), with and without cerebral lesions, and normotensive Wistar Kyoto (WK) rats. The levels of TBARS in the blood from healthy SHRSP were not significantly different from those of WK rats, while the values of SHRSP (male) with stroke were more than twice as high as those of healthy SHRSP. The activities of SOD and GSH-Px in stroke SHRSP were also statistically different from those of healthy SHRSP.
以硫代巴比妥酸反应性物质(TBARS)测定的脂质过氧化物水平,以及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性,在有或没有脑损伤的易中风自发性高血压大鼠(SHRSP)以及正常血压的Wistar Kyoto(WK)大鼠的血液中进行了检测。健康SHRSP血液中的TBARS水平与WK大鼠的水平无显著差异,而患有中风的SHRSP(雄性)的值比健康SHRSP的水平高出两倍多。中风SHRSP中SOD和GSH-Px的活性与健康SHRSP的活性也存在统计学差异。