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易患中风的自发性高血压大鼠中风时脂质过氧化物及相关酶活性的波动

Fluctuation of lipid peroxides and related enzyme activities at time of stroke in stroke-prone spontaneously hypertensive rats.

作者信息

Tomita I, Sano M, Serizawa S, Ohta K, Katou M

出版信息

Stroke. 1979 May-Jun;10(3):323-6. doi: 10.1161/01.str.10.3.323.

DOI:10.1161/01.str.10.3.323
PMID:462520
Abstract

The levels of lipid peroxides, determined as thiobarbituric acid reactive substances (TBARS), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were examined in the blood from stroke-prone spontaneously hypertensive rats (SHRSP), with and without cerebral lesions, and normotensive Wistar Kyoto (WK) rats. The levels of TBARS in the blood from healthy SHRSP were not significantly different from those of WK rats, while the values of SHRSP (male) with stroke were more than twice as high as those of healthy SHRSP. The activities of SOD and GSH-Px in stroke SHRSP were also statistically different from those of healthy SHRSP.

摘要

以硫代巴比妥酸反应性物质(TBARS)测定的脂质过氧化物水平,以及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性,在有或没有脑损伤的易中风自发性高血压大鼠(SHRSP)以及正常血压的Wistar Kyoto(WK)大鼠的血液中进行了检测。健康SHRSP血液中的TBARS水平与WK大鼠的水平无显著差异,而患有中风的SHRSP(雄性)的值比健康SHRSP的水平高出两倍多。中风SHRSP中SOD和GSH-Px的活性与健康SHRSP的活性也存在统计学差异。

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Fluctuation of lipid peroxides and related enzyme activities at time of stroke in stroke-prone spontaneously hypertensive rats.易患中风的自发性高血压大鼠中风时脂质过氧化物及相关酶活性的波动
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引用本文的文献

1
[Cell damage as reason for the formation of unsaturated fatty acid hydroperoxides].[细胞损伤作为不饱和脂肪酸氢过氧化物形成的原因]
Naturwissenschaften. 1995 Oct;82(10):452-60.
2
Determination of plasma malondialdehyde-like material and its clinical application in stroke patients.血浆丙二醛样物质的测定及其在脑卒中患者中的临床应用
J Clin Pathol. 1980 Oct;33(10):973-6. doi: 10.1136/jcp.33.10.973.
3
Potentiation of lipid peroxides by ischemia in rat brain.大鼠脑缺血对脂质过氧化物的增强作用。
Neurochem Res. 1982 Apr;7(4):437-54. doi: 10.1007/BF00965496.