医院感染中的R因子。
R factors in hospital infection.
作者信息
Anderson F M, Datta N, Shaw E J
出版信息
Br Med J. 1972 Jul 8;3(5818):82-5. doi: 10.1136/bmj.3.5818.82.
Abstract
In order to assess the clinical importance of R factors 524 "coliform" infections were studied in a general hospital. Of these, 95 were caused by Pseudomonas aeruginosa. Among the remaining 429, 43% were caused by drug-resistant enterobacteria; resistance was frequently multiple and determined by transmissible R factors. Choice of therapy was thus limited but in every case at least one antibiotic, effective in vitro, was still available.
摘要
为评估R因子的临床重要性，在一家综合医院对524例“大肠菌”感染进行了研究。其中，95例由铜绿假单胞菌引起。在其余429例中，43%由耐药性肠杆菌引起；耐药性通常是多重的，且由可传递的R因子决定。因此治疗选择有限，但在每种情况下至少仍有一种体外有效的抗生素可用。
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本文引用的文献
1
Occurrence of serious bacterial infections since introduction of antibacterial agents.自抗菌药物引入以来严重细菌感染的发生情况。
J Am Med Assoc. 1959 Aug 29;170:2188-97. doi: 10.1001/jama.1959.63010180008012.
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High level transferable resistance to gentamicin.对庆大霉素具有高水平可转移耐药性。
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Studies on the epidemiology of resistance (R) factors. I. Analysis of Klebsiella isolates in a general hospital. II. A prospective study of R factor transfer in the host.耐药（R）因子的流行病学研究。I. 综合医院克雷伯菌分离株分析。II. 宿主中R因子转移的前瞻性研究。
Ann Intern Med. 1969 Jul;71(1):1-9. doi: 10.7326/0003-4819-71-1-1.
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Transferable carbenicillin resistance in Pseudomonas aeruginosa.
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Trimethoprim resistance determined by R factors.由R因子决定的甲氧苄啶耐药性。
Br Med J. 1972 Mar 18;1(5802):726-8. doi: 10.1136/bmj.1.5802.726.
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Value of dilute inocula in cultural examination of sputum.痰液培养检查中稀释接种物的价值
Lancet. 1965 Nov 20;2(7421):1046-8. doi: 10.1016/s0140-6736(65)90572-6.
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Control of infection due to Klebsiella aerogenes in a neurosurgical unit by withdrawal of all antibiotics.通过停用所有抗生素控制神经外科病房中产气克雷伯菌引起的感染。
Lancet. 1970 Dec 12;2(7685):1213-5. doi: 10.1016/s0140-6736(70)92179-3.
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