Moller J K, Bak A L, Stenderup A, Zachariae H, Afzelius H
Antimicrob Agents Chemother. 1977 Mar;11(3):388-91. doi: 10.1128/AAC.11.3.388.
The patterns of drug resistance and the frequency of conjugative R plasmids in intestinal Escherichia coli from 88 patients treated for a skin disease (acne vulgaris) with low oral doses of tetracycline are reported. The proportion of patients with resistant bacteria was progressively greater in patients who received tetracycline for 1 week, 4 weeks, or longer (from 50 to 88%). No multiply drug-resistant bacteria were detected before treatment or after 1 week of treatment. After more than 4 weeks of treatment, multiply drug-resistant E. coli were isolated from about 50% of the patients. The origin and selection of R plasmid-determined multiple drug resistance are discussed.
报告了88例接受低剂量口服四环素治疗皮肤病（寻常痤疮）的患者肠道大肠杆菌中的耐药模式及接合性R质粒的频率。接受四环素治疗1周、4周或更长时间的患者中，耐药菌患者的比例逐渐增加（从50%增至88%）。治疗前或治疗1周后未检测到多重耐药菌。治疗超过4周后，约50%的患者分离出多重耐药大肠杆菌。文中讨论了R质粒介导的多重耐药的起源和选择。
