Louie J S, Goldberg L S
Clin Exp Immunol. 1972 Jul;11(3):469-74.
Mechanisms of cellular immunity were studied in an anergic female with recurrent bacterial infections. Lymphocytes transformed and produced cytotoxin in the presence of phytohaemagglutinin, but elaborated only migration inhibitory factor (MIF) in response to specific antigen. Monocytes isolated from the patient's peripheral blood were unresponsive to autologous MIF and to homologous MIF from two of three healthy adults. Humoral immunity, complement and neutrophil bactericidal activity were intact. The lymphocyte-monocyte defects found in this patient suggest that they were responsible for the anergy and predisposition to bacterial infections.
对一名患有复发性细菌感染的无反应性女性的细胞免疫机制进行了研究。淋巴细胞在植物血凝素存在的情况下发生转化并产生细胞毒素，但仅对特异性抗原产生迁移抑制因子（MIF）。从患者外周血中分离出的单核细胞对自身MIF以及来自三名健康成年人中两名的同种MIF无反应。体液免疫、补体和中性粒细胞杀菌活性均正常。该患者中发现的淋巴细胞-单核细胞缺陷表明，它们是导致无反应性和易患细菌感染的原因。
