van der Waaij D, Berghuis J M, Lekkerkerk J E
J Hyg (Lond). 1972 Dec;70(4):605-10. doi: 10.1017/s0022172400022464.
During systemic treatment of mice with ampicillin or streptomycin, oral contaminations with exogenous bacterial species resulted in an abnormal colonization pattern. The contaminants persisted much longer and in much higher concentrations in the caecum of systemically treated mice than in control animals. Spread of the contaminant into the mesenteric lymph nodes and the spleen was found much more often in the antibiotic treated group. This, however, was only seen when the contaminant was ;resistant' to the antibiotic injected. The experiments suggest that the ;CR-inducing species' of the microflora live in close contact with the mucosa and therefore could be identical with the anaerobic tapered rods described by Savage & Dubos (1968).
在用氨苄青霉素或链霉素对小鼠进行全身治疗期间，外源细菌物种的口腔污染导致了异常的定植模式。与对照动物相比，污染物在全身治疗小鼠的盲肠中持续存在的时间长得多，浓度也高得多。在抗生素治疗组中，污染物扩散到肠系膜淋巴结和脾脏的情况更为常见。然而，这仅在污染物对注射的抗生素“耐药”时才会出现。实验表明，微生物群落中“诱导CR的物种”与粘膜密切接触，因此可能与萨维奇和杜博斯（1968年）描述的厌氧锥形杆菌相同。
