Valman H B, Heath C D, Brown R J
Br Med J. 1972 Sep 2;3(5826):547-50. doi: 10.1136/bmj.3.5826.547.
In a feeding trial 66 infants of low birth weight received continuous intragastric milk feeds from the fourth hour of life, starting with 60 ml/kg/24 hr and reaching a maximum of 300 ml/kg/24 hr on the ninth day. Each infant received only full-strength milk, which was either expressed human breast milk or SMA-S26 (a proprietary low-protein adapted cows' milk) or half-cream Regal milk (partly-skimmed evaporated cows' milk). For various reasons 10 babies had to be withdrawn, and the final assessment was made on the 56 who completed the trial successfully.Persistent vomiting was a problem in only four infants. In two of them the trial was continued after gastric lavage and in the other two vomiting stopped when the volume was reduced. Despite a careful search no evidence was found of aspiration of feeds in any infant. Continuous intragastric milk infusion was shown to be a safe method of feeding infants of low birth weight and SMA-S26 was almost as well tolerated as human milk. Because of the high-protein content of half-cream cows' milk preparations and the resultant high plasma amino-acid levels when they are given in these large volumes they should be avoided for this type of feeding although they produce better weight gains in the first week of life.
在一项喂养试验中，66名低出生体重儿从出生后第4小时开始接受持续胃内喂乳，起始量为60毫升/千克/24小时，到第9天增至最大量300毫升/千克/24小时。每名婴儿仅接受全浓度奶，即挤出的母乳、SMA-S26（一种特制的低蛋白配方牛奶）或半脱脂富豪牛奶（部分脱脂的蒸发牛奶）。由于各种原因，10名婴儿不得不退出试验，最终评估是对成功完成试验的56名婴儿进行的。持续性呕吐仅在4名婴儿中是个问题。其中2名婴儿在洗胃后继续试验，另外2名婴儿在奶量减少后呕吐停止。尽管进行了仔细检查，但未在任何婴儿中发现奶液误吸的证据。持续胃内注奶被证明是喂养低出生体重儿的一种安全方法，SMA-S26的耐受性几乎与母乳一样好。由于半脱脂牛奶制品的高蛋白含量以及大量喂食时所导致的高血浆氨基酸水平，尽管它们在出生后第一周能使体重增加得更好，但在这类喂养中应避免使用。
