Belton N R, Cockburn F, Forfar J O, Giles M M, Kirkwood J, Smith J, Thistlethwaite D, Turner T L, Wilkinson E M
Arch Dis Child. 1977 Mar;52(3):167-75. doi: 10.1136/adc.52.3.167.
A clinical and biochemical evaluation has been made of a new milk formula, Modified Carnation milk (MCM), based on cows' milk but with the mineral content and concentration of caloric nutrients altered to make it correspond more closely to human milk. MCM produced higher plasma calcium and magnesium concentrations in 6-day-old infants than those produced by unmodified evaporated and dried milks, achieving concentrations closer to those of breast milk. Plasma free amino acid concentrations in MCM-fed infants are nearer breast-fed values than those in unmodified milk-fed infants where higher individual plasma amino acid concentrations persist during the first 3 months. MCM-fed infants had low plasma urea concentrations and lower urine osmolalities at 6 days, 3 weeks, 6 weeks, 3 months, and 6 months than infants fed on the evaporated and dried milks, and similar plasma urea and urine osmolalities to those of breast-fed infants. MCM is likely to be superior to unmodified evaporated and dried milks in preventing convulsions of the hypocalcaemic/hypomagnesaemic/hyperphosphataemic type, and seems less likely to cause hypertonic dehydration. MCM is easily prepared, readily accepted by babies, and appears to be nutritionally adequate for the feeding of term infants.
对一种新的奶粉——改良康乃馨奶粉（MCM）进行了临床和生化评估。该奶粉以牛奶为基础，但矿物质含量和热量营养素浓度有所改变，使其更接近母乳。与未改良的蒸发奶和干奶相比，MCM在6日龄婴儿中产生了更高的血浆钙和镁浓度，达到了更接近母乳的浓度。与未改良奶粉喂养的婴儿相比，MCM喂养的婴儿血浆游离氨基酸浓度更接近母乳喂养婴儿的值，未改良奶粉喂养的婴儿在头3个月中个别血浆氨基酸浓度持续较高。在6日龄、3周龄、6周龄、3月龄和6月龄时，MCM喂养的婴儿血浆尿素浓度较低，尿渗透压也低于食用蒸发奶和干奶的婴儿，其血浆尿素和尿渗透压与母乳喂养婴儿相似。在预防低钙血症/低镁血症/高磷血症型惊厥方面，MCM可能优于未改良的蒸发奶和干奶，而且似乎不太可能导致高渗性脱水。MCM易于制备，婴儿容易接受，而且对于足月儿喂养而言，其营养似乎足够。
