Tobin B M, Jones D M
J Clin Pathol. 1972 Jul;25(7):583-5. doi: 10.1136/jcp.25.7.583.
Specimens of cerebrospinal fluid and serum from 22 cases of meningococcal infection were examined by immunoelectroosmophoresis and the results compared with those obtained by microscopy and culture. The results were the same except that three of 10 cases of group B infection were not diagnosed by immunoelectroosmophoresis and two of 10 cases of group C infection were not diagnosed by culture. The sensitivity of the method depends on the potency of the antiserum used and antisera from commercial sources were satisfactory except for those prepared against group B meningococci. The method may be more sensitive than microscopy and culture under certain conditions, in particular, where the patient has already begun antibiotic treatment, where the specimens have become contaminated and, where the infecting organism is either a group A or group C meningococcus.
采用免疫电渗电泳法对22例脑膜炎球菌感染患者的脑脊液和血清样本进行检测，并将结果与显微镜检查和培养法的结果进行比较。除10例B组感染中有3例未通过免疫电渗电泳法诊断出来，以及10例C组感染中有2例未通过培养法诊断出来外，结果相同。该方法的灵敏度取决于所用抗血清的效价，除针对B组脑膜炎球菌制备的抗血清外，市售抗血清的效果令人满意。在某些情况下，特别是患者已经开始抗生素治疗、样本已被污染以及感染病原体为A组或C组脑膜炎球菌时，该方法可能比显微镜检查和培养法更灵敏。
