人肝脏原位移植后的血清补体
Serum complement after orthotopic transplantation of the human liver.
作者信息
Torisu M, Yokoyama T, Kohler P F, Durst A L, Martineau G, Schroter G, Amemiya H, Groth C G, Starzl T E
出版信息
Clin Exp Immunol. 1972 Sep;12(1):21-30.
Abstract
In five patients with terminal liver failure, replacement of the diseased liver with a well functioning homograft restored markedly depressed total complement and C4 and C3 to normal levels. Concomitantly, C5 protein also increased. Postoperatively, two patients developed a marked drop in C4 and C3 probably in relation to homograft rejection. In contrast, serum hepatitis and biliary obstruction were not accompanied by significant changes. It is concluded that the liver is an important source of synthesis of C4, C3 and C5 and that complement assays might aid in otherwise equivocal diagnosis of hepatic homograft rejection.
摘要
在5例终末期肝衰竭患者中，用功能良好的同种异体移植物替换病变肝脏后，显著降低的总补体以及C4和C3恢复到正常水平。同时，C5蛋白也增加。术后，两名患者的C4和C3显著下降，可能与同种异体移植物排斥反应有关。相比之下，血清性肝炎和胆道梗阻并未伴随显著变化。结论是肝脏是C4、C3和C5合成的重要来源，补体检测可能有助于对肝同种异体移植排斥反应进行其他难以明确的诊断。
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