Potter B J, Trueman A M, Jones E A
Gut. 1973 Jun;14(6):451-6. doi: 10.1136/gut.14.6.451.
Total serum haemolytic complement activity (CH(50)) and the serum concentrations of both the third and fourth components of the complement system (C3 and C4) have been measured in 29 control subjects, 92 patients with chronic hepatocellular disease, and eight patients with large duct biliary tract obstruction. The mean C4 concentration was reduced in all types of chronic liver disease studied. However, the mean CH(50) and C3 values were increased in compensated primary biliary cirrhosis, were relatively normal in non-cirrhotic chronic active hepatitis, and were decreased in cryptogenic cirrhosis, particularly when ascites was present. There was a significant correlation between CH(50) and C3 in patients with chronic liver disease but no correlation between CH(50) and C4 or between C3 and C4. Raised values for CH(50) and C3 in primary biliary cirrhosis may be due at least in part to concomitant cholestasis since these values tend to be raised in patients with large duct biliary tract obstruction. Although primary biliary cirrhosis, chronic active hepatitis, and cryptogenic cirrhosis are considered to be part of a spectrum of chronic liver disease associated with disturbed immunity, the results of this study emphasize that there are clearly definable differences between these diseases in terms of the pattern of changes in serum complement.
对29名对照者、92例慢性肝细胞疾病患者和8例大胆管胆道梗阻患者测定了血清总溶血补体活性（CH50）以及补体系统第三和第四成分（C3和C4）的血清浓度。在所研究的所有类型慢性肝病中，平均C4浓度均降低。然而，在代偿性原发性胆汁性肝硬化中，平均CH50和C3值升高；在非肝硬化性慢性活动性肝炎中相对正常；在隐源性肝硬化中降低，尤其是出现腹水时。慢性肝病患者中CH50与C3之间存在显著相关性，但CH50与C4之间以及C3与C4之间无相关性。原发性胆汁性肝硬化中CH50和C3值升高可能至少部分归因于合并胆汁淤积，因为在大胆管胆道梗阻患者中这些值往往升高。虽然原发性胆汁性肝硬化、慢性活动性肝炎和隐源性肝硬化被认为是与免疫紊乱相关的一系列慢性肝病的一部分，但本研究结果强调，这些疾病在血清补体变化模式方面存在明显可定义的差异。
