桥本甲状腺炎中的细胞毒性淋巴细胞。
Cytotoxic lymphocytes in Hashimoto's thyroiditis.
作者信息
Podleski W K
出版信息
Clin Exp Immunol. 1972 Aug;11(4):543-8.
Abstract
The ability of peripheral lymphocytes from patients with Hashimoto's disease to destroy target cells coated with thyroid-related-autoantigens has been demonstrated. Direct cytotoxicity was demonstrable against mouse mastocytoma target cells coated with human thyroglobulin or microsomal antigen from thyrotoxic thyroid glands. No correlation was noted between circulating antibody and the ability of these cells to be cytotoxic. The significance of the expression of cell-mediated immunity in this method is discussed.
摘要
已证实桥本氏病患者外周淋巴细胞破坏包被有甲状腺相关自身抗原的靶细胞的能力。对包被有人甲状腺球蛋白或来自甲状腺毒症甲状腺的微粒体抗原的小鼠肥大细胞瘤靶细胞可显示出直接细胞毒性。循环抗体与这些细胞的细胞毒性能力之间未发现相关性。讨论了这种方法中细胞介导免疫表达的意义。
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Cellular and humoral response to transplantation antigens. I. Development of alloantibody-forming cells and cytotoxic lymphocytes in the graft-versus-host reaction.对移植抗原的细胞和体液反应。I. 移植物抗宿主反应中同种抗体形成细胞和细胞毒性淋巴细胞的发育。
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