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通过免疫荧光法测定抗淋巴细胞血清和球蛋白的抗体滴度及其与免疫抑制活性的相关性。

Antibody titres of antilymphocytic sera and globulins determined by immunofluorescence and their correlation with immunosuppressive activity.

作者信息

Thomas D, Woodrooffe J G, Mosedale B, Ward P D, Zola H, Edwards D C, Balner H

出版信息

Clin Exp Immunol. 1972 Aug;11(4):569-78.

PMID:4628577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553702/
Abstract

Human and mouse lymphocytes have been treated with the appropriate antilymphocytic serum or globulin and the indirect fluorescent technique applied. A method of scoring the observed fluorescence has been devised. A good general degree of correlation has been demonstrated between the antibody titres of the antilymphocytic sera and globulins, determined by immunofluorescence and the immunosuppressive activity as measured by graft prolongation. The test is reliable, rapid and reproducible, but absolute reliance on the test is not advocated as a precise measure of immunosuppressive activity. The immunofluorescent technique is invaluable in the analysis of serum samples from horses undergoing active immunization.

摘要

已用适当的抗淋巴细胞血清或球蛋白处理人及小鼠淋巴细胞，并应用间接荧光技术。已设计出一种对观察到的荧光进行评分的方法。通过免疫荧光测定的抗淋巴细胞血清和球蛋白的抗体滴度与通过移植延长测定的免疫抑制活性之间已显示出良好的总体相关性。该试验可靠、快速且可重复，但不提倡将其作为免疫抑制活性的精确测量方法而完全依赖该试验。免疫荧光技术在分析正在进行主动免疫的马的血清样本中非常有用。

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本文引用的文献

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Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro.对水痘和带状疱疹病原体在体外繁殖进行的荧光抗体研究。
Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):789-94. doi: 10.3181/00379727-86-21235.
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The effect of heterologous antisera and rheumatoid factor on the synthesis of DNA and protein by human peripheral lymphocytes.异源抗血清和类风湿因子对人外周血淋巴细胞DNA和蛋白质合成的影响。
Immunochemistry. 1966 Sep;3(5):359-71. doi: 10.1016/0019-2791(66)90174-1.
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A procedure for separating viable lymphocytes from human blood and some studies on their susceptibility to hypotonic shocks.一种从人血中分离活淋巴细胞的方法及其对低渗休克敏感性的一些研究。
Br J Haematol. 1966 Jul;12(4):433-46. doi: 10.1111/j.1365-2141.1966.tb05652.x.
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The viability of human spleen cells after cooling in vitro.
Br J Surg. 1966 Sep;53(9):794-8. doi: 10.1002/bjs.1800530916.
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Defibrination of normal human blood for in vitro cell studies.用于体外细胞研究的正常人血液去纤维蛋白处理
Nature. 1968 Apr 13;218(5137):178-80. doi: 10.1038/218178a0.
6
The use of the indirect fluorescent antibody technique in assessing the activity of antilymphocytic sera and antilymphocytic globulins.间接荧光抗体技术在评估抗淋巴细胞血清和抗淋巴细胞球蛋白活性中的应用。
Clin Exp Immunol. 1971 Jun;8(6):987-91.
7
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Transplantation. 1971 Jul;12(1):49-53. doi: 10.1097/00007890-197107000-00008.
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Testing of antihuman lymphocyte sera in chimpanzees and lower primates.
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In vitro rosette inhibition by antihuman antilymphocyte serum. Correlation with skin graft prolongation in subhuman primates.抗人抗淋巴细胞血清的体外玫瑰花结抑制作用。与亚人类灵长类动物皮肤移植延长的相关性。
Transplantation. 1969 Sep;8(3):265-80. doi: 10.1097/00007890-196909000-00008.

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