Tsilinskii Ia Ia, Karpova E F, Prianichnikova L V, Koptiaeva I B, Surkov V V
Vopr Virusol. 1979 May-Jun(3):271-7.
An acute infection of HeLa cell cultures with a ts mutant of Venezuelan equine encephalomyelitis (VEE) virus may have different outcomes ranging from formation of a chronic virus-carrier state to complete elimination of virus from the culture. One of the possibilities is also a short-time carrier state (up to 10 passages) of the virus genome apparently existing in the form of DNA-provirus. The carrier state of virus genetic material in this case is indicated by the infectivity of cellular DNA and the presence in it of sequences homologous to those of virion RNA. The genetic material of VEE virus in HeLa cell cultures with signs of infection of the integrative type is also demonstrable by its complementation with exogenous ts-mutants.
用委内瑞拉马脑炎（VEE）病毒的温度敏感突变体对HeLa细胞培养物进行急性感染，可能会有不同的结果，从形成慢性病毒携带状态到从培养物中完全清除病毒。其中一种可能性是病毒基因组存在短时间的携带状态（最多传代10次），显然是以DNA原病毒的形式存在。在这种情况下，病毒遗传物质的携带状态通过细胞DNA的感染性以及其中与病毒粒子RNA序列同源的序列的存在来表明。在具有整合型感染迹象的HeLa细胞培养物中，VEE病毒的遗传物质通过其与外源性温度敏感突变体的互补作用也可得到证实。
