Drynov I D, Melik-Andreasian G G, Puchkova N I, Uryvaev L V, Barinskiĭ I F
Vopr Virusol. 1981 Sep-Oct(5):572-4.
A model of chronic infection in the system of T-lymphocyte--VEE virus was made. Production of infectious VEE (up to 6.0 lg PFU/ml), tissue culture interferon levels (less than 10 units/ml), accumulation of virus-specific antigen in chronically infected continuous human T-lymphocytes (78%) were studied. The presence of virus-specific sequence in DNA from infected cells was studied by the method of molecular hybridization and found not to exceed one DNA replica of virus genome per three cells of chronically infected T-lymphocyte culture.
建立了T淋巴细胞系统中委内瑞拉马脑炎病毒（VEE病毒）的慢性感染模型。研究了感染性VEE病毒的产生（高达6.0 lg PFU/ml）、组织培养中的干扰素水平（低于10单位/ml）以及慢性感染的连续人T淋巴细胞中病毒特异性抗原的积累（78%）。通过分子杂交方法研究了感染细胞DNA中病毒特异性序列的存在情况，发现慢性感染的T淋巴细胞培养物中每三个细胞中病毒基因组的DNA复制体不超过一个。
