Stein G, Stelzner A
Z Gesamte Inn Med. 1979 Feb 15;34(4):117-23.
In the serum of patients with chronic pyelonephritis IgG, IgM, IgA, IgD and autoantibodies against organ- and species-specific renal antigens were determined. Clinical questions concerned relations to the activity of the disease and the renal function. The Ig-mean-values lying within the biological norm could be precised by taking into consideration individual biological boundary titres and relative ratio values. Pictures of tendency led to the estimation that increases of IgG and IgD appear in severely restricted renal function in normal or decreased IgM. Increases may be a criterion of activity in diseases with normal or slightly restricted renal function. IgA determinations remained without any evidence.-- Autoantibodies were found in 32,5%, increased titres were a sign of deteriorated renal function. The apparently given possibility of a humoral immunogramme for the chronic pyelonephritis is discussed, in which case a combination with other test parameters seems to be necessary.
对慢性肾盂肾炎患者血清中的IgG、IgM、IgA、IgD以及针对器官特异性和物种特异性肾脏抗原的自身抗体进行了测定。临床问题涉及与疾病活动度和肾功能的关系。通过考虑个体生物学临界滴度和相对比值，可以精确确定处于生物学正常范围内的Ig平均值。趋势图显示，在IgM正常或降低的情况下，严重肾功能受限会出现IgG和IgD升高。在肾功能正常或轻度受限的疾病中，升高可能是活动度的一个标准。IgA测定未发现任何证据。——32.5%的患者发现了自身抗体，滴度升高是肾功能恶化的迹象。文中讨论了慢性肾盂肾炎体液免疫图谱的明显可能性，在这种情况下，似乎有必要与其他检测参数相结合。
