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恰加斯病中的免疫球蛋白及其他血清学参数：慢性消化型中IgA水平升高的证据。

Immunoglobulins and other serological parameters in Chagas' disease: evidence for increased IgA levels in the chronic digestive form.

作者信息

Sá Ferreira J A, Galvão-Castro B, Macedo W, Castro C

出版信息

Clin Exp Immunol. 1983 May;52(2):266-70.

PMID:6407792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535837/
Abstract

Immunoglobulin levels were measured in serum samples from 36 patients with different clinical forms of chronic Chagas' disease. Increased IgA levels were observed in 50% of the patients in the chronic digestive group and there was a significant correlation with the severity of the disease. IgG and IgM levels were within the normal range. Anti-ssDNA antibodies and EVI (endothelium, vessels and interstitium) antibodies were found in some patients with different clinical forms of the disease.

摘要

对36例不同临床类型的慢性恰加斯病患者的血清样本进行了免疫球蛋白水平检测。在慢性消化型组中，50%的患者观察到IgA水平升高，且与疾病严重程度存在显著相关性。IgG和IgM水平在正常范围内。在一些不同临床类型的疾病患者中发现了抗单链DNA抗体和EVI（内皮、血管和间质）抗体。

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PLoS Negl Trop Dis. 2017 Jul 19;11(7):e0005796. doi: 10.1371/journal.pntd.0005796. eCollection 2017 Jul.
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J Clin Microbiol. 1988 Oct;26(10):2101-4. doi: 10.1128/jcm.26.10.2101-2104.1988.

本文引用的文献

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[Artificial xenodiagnosis; new process; first positive results].[人工异源诊断；新方法；首次阳性结果]
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Immunity to Trypanosoma cruzi.对克氏锥虫的免疫力。
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Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
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Antibody response and immunoglobulin levels in humans with acute or chronic Trypanosoma cruzi infections (Chagas' disease).患有急性或慢性克氏锥虫感染（恰加斯病）的人类的抗体反应和免疫球蛋白水平。
J Trop Med Hyg. 1973 Feb;76(2):45-7.
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Secretory immunoglobulins.分泌型免疫球蛋白
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Hemagglutination with preserved, sensitized cells, a practical test for routine serologic diagnosis of American trypanosomiasis.用保存的致敏细胞进行血凝反应，这是美洲锥虫病常规血清学诊断的一种实用检测方法。
Rev Inst Med Trop Sao Paulo. 1973 Mar-Apr;15(2):81-5.
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Uptake and transport of macromolecules by the intestine. Possible role in clinical disorders.肠道对大分子的摄取与转运。在临床疾病中的可能作用。
Gastroenterology. 1974 Sep;67(3):531-50.
10
Chagasic cardiopathy. Demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures.恰加斯病性心脏病。一种与心内膜和血管结构发生反应的血清γ球蛋白因子的展示。
Circulation. 1974 Jan;49(1):13-21. doi: 10.1161/01.cir.49.1.13.