黑腹果蝇核糖体RNA基因多样性的调控
Regulation of ribosomal RNA gene multiplicity in Drosophila melanogaster.
作者信息
Tartof K D
出版信息
Genetics. 1973 Jan;73(1):57-71. doi: 10.1093/genetics/73.1.57.
Abstract
The ribosomal RNA (rRNA) genes of Drosophila melanogaster can undergo a disproportionate replication of their number. This occurs when the cluster of rRNA genes (rDNA) of one chromosome is maintained with a homologous chromosome that is completely or partially deficient in its rDNA. Under appropriate genetic conditions, it appears that disproportionate rDNA replication can be generated at the level of both somatic and germ line cells. In the latter case, mutants partially deficient for rDNA can increase their rRNA gene number to the wild type level and transmit this new genotype to successive generations.
摘要
黑腹果蝇的核糖体RNA（rRNA）基因可经历数量上的不均衡复制。当一条染色体的rRNA基因簇（rDNA）与一条rDNA完全或部分缺失的同源染色体保持在一起时，就会发生这种情况。在适当的遗传条件下，似乎在体细胞和生殖细胞水平上都能产生不均衡的rDNA复制。在后一种情况下，rDNA部分缺失的突变体可以将其rRNA基因数量增加到野生型水平，并将这种新基因型传递给后代。
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