• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗索状因子抗体对小鼠实验性结核病的影响。

Effect of anti-cord factor antibody on experimental tuberculosis in mice.

作者信息

Kato M

出版信息

Infect Immun. 1973 Jan;7(1):14-21. doi: 10.1128/iai.7.1.14-21.1973.

DOI:10.1128/iai.7.1.14-21.1973
PMID:4632133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422632/
Abstract

Either active immunization with trehalose-6, 6'-dimycolate (cord factor)-methylated bovine serum albumin complex or passive transfer of rabbit anti-cord factor serum induced in mice an enhanced resistance against infection with virulent human Mycobacterium tuberculosis. This suggests that the anti-cord factor antibody exerts an infection-protecting effect by neutralizing the toxic action of cord factor during the course of living virulent infection with tubercle bacilli. The protective effect of active immunization with cord factor-methylated bovine serum albumin complex and of anti-cord factor serum was found to be specific for the tuberculous infection among a number of experimental infections in mice with a variety of cytopathogenic microorganisms tested.

摘要

用海藻糖-6,6'-二甲酰基海藻糖（索状因子）-甲基化牛血清白蛋白复合物进行主动免疫，或在小鼠中被动转移兔抗索状因子血清，均可增强其对强毒人型结核分枝杆菌感染的抵抗力。这表明抗索状因子抗体在结核杆菌活的强毒感染过程中，通过中和索状因子的毒性作用发挥抗感染保护作用。在对小鼠进行多种细胞致病性微生物试验的一系列实验感染中，发现用索状因子-甲基化牛血清白蛋白复合物进行主动免疫和抗索状因子血清的保护作用对结核感染具有特异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/531d/422632/ed6ac6758511/iai00253-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/531d/422632/ed6ac6758511/iai00253-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/531d/422632/ed6ac6758511/iai00253-0027-a.jpg

相似文献

1
Effect of anti-cord factor antibody on experimental tuberculosis in mice.抗索状因子抗体对小鼠实验性结核病的影响。
Infect Immun. 1973 Jan;7(1):14-21. doi: 10.1128/iai.7.1.14-21.1973.
2
Immunochemical properties of anti-cord factor antibody.抗索状因子抗体的免疫化学特性
Infect Immun. 1973 Jan;7(1):9-13. doi: 10.1128/iai.7.1.9-13.1973.
3
Immune response to Mycobacterium tuberculosis in rats.大鼠对结核分枝杆菌的免疫反应。
Infect Immun. 1973 Aug;8(2):182-9. doi: 10.1128/iai.8.2.182-189.1973.
4
Antibody formation to trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.针对结核分枝杆菌海藻糖-6,6'-二霉菌酸酯（索状因子）的抗体形成
Infect Immun. 1972 Feb;5(2):203-12. doi: 10.1128/iai.5.2.203-212.1972.
5
Production and partial characterization of anti-cord factor (trehalose-6,6'-dimycolate) IgG antibody in rabbits recognizing mycolic acid subclasses of Mycobacterium tuberculosis or Mycobacterium avium.兔体内抗结核分枝杆菌或鸟分枝杆菌的分枝菌酸亚类的抗索状因子（海藻糖-6,6'-二霉菌酸酯）IgG抗体的产生及部分特性研究
FEMS Immunol Med Microbiol. 1999 Jun;24(2):141-9. doi: 10.1111/j.1574-695X.1999.tb01275.x.
6
Immunogenicity of mannophosphoinositides of mycobacteria: effect of cord factor (trehalose-6,6'-dimycolate).分枝杆菌甘露糖磷酸肌醇的免疫原性：索状因子（海藻糖-6,6'-二霉菌酸酯）的作用。
Folia Microbiol (Praha). 1990;35(6):570-7. doi: 10.1007/BF02819993.
7
Anti-cord factor (trehalose 6,6'dimycolate) IgG antibody in tuberculosis patients recognizes mycolic acid subclasses.结核病患者体内的抗索状因子（海藻糖6,6'-二霉菌酸酯）IgG抗体可识别分枝菌酸亚类。
Microbiol Immunol. 1999;43(9):863-9. doi: 10.1111/j.1348-0421.1999.tb01221.x.
8
The immunology of antituberculous immunity.抗结核免疫的免疫学
Am Rev Respir Dis. 1968 Mar;97(3):337-44. doi: 10.1164/arrd.1968.97.3.337.
9
Modulating effect of passive immunization with anti-Mycobacterium tuberculosis antibodies on humoral response in BCG-infected mice.用抗结核分枝杆菌抗体进行被动免疫对卡介苗感染小鼠体液反应的调节作用。
Int Arch Allergy Appl Immunol. 1980;63(4):446-54. doi: 10.1159/000232661.
10
Passive serum therapy with polyclonal antibodies against Mycobacterium tuberculosis protects against post-chemotherapy relapse of tuberculosis infection in SCID mice.用抗结核分枝杆菌多克隆抗体进行的被动血清疗法可预防SCID小鼠化疗后结核感染的复发。
Microbes Infect. 2006 Apr;8(5):1252-9. doi: 10.1016/j.micinf.2005.12.004. Epub 2006 Jan 27.

引用本文的文献

1
Immunochemical properties of anti-cord factor antibody.抗索状因子抗体的免疫化学特性
Infect Immun. 1973 Jan;7(1):9-13. doi: 10.1128/iai.7.1.9-13.1973.
2
Role of cord factor in the modulation of infection caused by mycobacteria.索状因子在分枝杆菌引起的感染调节中的作用。
Am J Pathol. 1985 Feb;118(2):238-47.
3
Protective immunity to experimental tuberculosis by mannophosphoinositides of mycobacteria.分枝杆菌甘露糖磷酸肌醇对实验性结核病的保护性免疫

本文引用的文献

1
Studies on the virulence of tubercle bacilli; isolation and biological properties of a constituent of virulent organisms.结核杆菌毒力研究；强毒株一种成分的分离及其生物学特性
J Exp Med. 1950 Feb;91(2):197-218, pl. doi: 10.1084/jem.91.2.197.
2
Studies on the virulence of Tubercle bacilli; the effect of cord factor on murine tuberculosis.结核杆菌毒力的研究；索状因子对小鼠结核病的影响。
Br J Exp Pathol. 1955 Feb;36(1):8-17.
3
Biologic and biochemical activities of cord factor; with special reference to its role in the virulence of tubercle bacilli.
Med Microbiol Immunol. 1988;177(5):265-84. doi: 10.1007/BF00189412.
4
Cord factor (alpha,alpha-trehalose 6,6'-dimycolate) inhibits fusion between phospholipid vesicles.索状因子（α,α-海藻糖6,6'-二霉菌酸酯）抑制磷脂囊泡之间的融合。
Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):737-40. doi: 10.1073/pnas.88.3.737.
5
Immunogenicity of mannophosphoinositides of mycobacteria: effect of cord factor (trehalose-6,6'-dimycolate).分枝杆菌甘露糖磷酸肌醇的免疫原性：索状因子（海藻糖-6,6'-二霉菌酸酯）的作用。
Folia Microbiol (Praha). 1990;35(6):570-7. doi: 10.1007/BF02819993.
6
Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties.分枝杆菌及相关生物体的细胞壁；化学性质与免疫刺激特性
Mol Cell Biochem. 1975 May 30;7(2):87-104. doi: 10.1007/BF01792076.
7
Granulomagenic activity of serologically active glycolipids from Mycobacterium bovis BCG.来自卡介苗的血清活性糖脂的致肉芽肿活性。
Infect Immun. 1976 Dec;14(6):1369-74. doi: 10.1128/iai.14.6.1369-1374.1976.
8
Mycobacterium.分枝杆菌属
Bacteriol Rev. 1977 Mar;41(1):217-372. doi: 10.1128/br.41.1.217-372.1977.
Am Rev Tuberc. 1958 Mar;77(3):482-91. doi: 10.1164/artpd.1958.77.3.482.
4
Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.用海藻糖-6,6-二霉菌酸酯（索状因子）和活卡介苗治疗的小鼠中，对乌拉坦诱导的肺腺瘤的抑制作用
Science. 1971 Dec 17;174(4015):1240-2. doi: 10.1126/science.174.4015.1240.
5
Granuloma formation induced in mice by chemically defined mycobacterial fractions.化学定义的分枝杆菌组分在小鼠中诱导形成肉芽肿。
J Bacteriol. 1969 Oct;100(1):95-102. doi: 10.1128/jb.100.1.95-102.1969.
6
Studies of a biochemical lesion in experimental tuberculosis in mice. XI. Mitochondrial swelling induced by cord factor in vitro.
Am Rev Respir Dis. 1969 Jul;100(1):47-53. doi: 10.1164/arrd.1969.100.1.47.
7
Studies of a biochemical lesion in experimental tuberculosis in mice. IX. Response of respiratory enzymes in immune mouse liver to cord factor and tuberculin PPD.
Am Rev Respir Dis. 1969 Jan;99(1):112-5. doi: 10.1164/arrd.1969.99.1.112.
8
Studies of a biochemical lesion in experimental tuberculosis in mice. VII. Structural and functional damage in mouse liver mitochondria under the toxic action of cord factor.
Am Rev Respir Dis. 1968 Aug;98(2):260-9. doi: 10.1164/arrd.1968.98.2.260.
9
Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions.用分枝杆菌组分预处理的小鼠对绵羊红细胞的免疫反应。
Infect Immun. 1971 Sep;4(3):256-63. doi: 10.1128/iai.4.3.256-263.1971.
10
Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli.分枝杆菌组分和卡介苗杆菌诱导的小鼠足垫及引流淋巴结中的细胞反应。
Infect Immun. 1971 Sep;4(3):245-55. doi: 10.1128/iai.4.3.245-255.1971.