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1
Protection of mice against vaccinia virus by bacterial infection and sustained stimulation with specific bacterial antigens.通过细菌感染和特定细菌抗原的持续刺激来保护小鼠免受痘苗病毒感染。
Infect Immun. 1973 Jan;7(1):62-7. doi: 10.1128/iai.7.1.62-67.1973.
2
Subcutaneous administration of modified vaccinia virus Ankara expressing an Ag85B-ESAT6 fusion protein, but not an adenovirus-based vaccine, protects mice against intravenous challenge with Mycobacterium tuberculosis.经修饰的安卡拉牛痘病毒皮下给药表达 Ag85B-ESAT6 融合蛋白，但不是基于腺病毒的疫苗，可保护小鼠免受结核分枝杆菌静脉内攻击。
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Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.痘苗病毒H3L包膜蛋白是人类中和抗体的主要靶标，并能引发针对小鼠致死性攻击的保护作用。
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The immune response to infection with vaccinia virus in mice. II. Appearance of hypersensitivity, production of macrophage migration inhibitory factor and transformation of spleen cells in response to virus antigens.小鼠对痘苗病毒感染的免疫反应。II. 超敏反应的出现、巨噬细胞移动抑制因子的产生以及脾细胞对病毒抗原的反应性转化
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Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara.使用黏膜给药并用重组改良安卡拉痘病毒加强免疫，卡介苗对结核分枝杆菌的免疫原性和保护效力增强。
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Lack of detectable circulating interferon in mice protected against vaccinia virus by induction and elicitation with bacterial systems.用细菌系统诱导和激发可使小鼠免受天花病毒感染，而循环干扰素则无法检测到。
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4
Detection of nonspecific resistance to Listeria monocytogenes in rabbits infected with Treponema pallidum.感染梅毒螺旋体的家兔对单核细胞增生李斯特菌非特异性抵抗力的检测
Infect Immun. 1974 Apr;9(4):658-62. doi: 10.1128/iai.9.4.658-662.1974.
5
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7
The immune response to infection with vaccinia virus in mice. II. Appearance of hypersensitivity, production of macrophage migration inhibitory factor and transformation of spleen cells in response to virus antigens.小鼠对痘苗病毒感染的免疫反应。II. 超敏反应的出现、巨噬细胞移动抑制因子的产生以及脾细胞对病毒抗原的反应性转化
J Hyg (Lond). 1975 Jun;74(3):315-27. doi: 10.1017/s0022172400046830.
8
Nonspecific resistance to Listeria monocytogenes in mice infected and elicited with Staphylococcus aureus.感染金黄色葡萄球菌并引发免疫反应的小鼠对单核细胞增生李斯特菌的非特异性抵抗力。
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9
Effect macrophage activation on infection with Treponema pallidum.巨噬细胞激活对梅毒螺旋体感染的影响。
Infect Immun. 1975 Sep;12(3):505-11. doi: 10.1128/iai.12.3.505-511.1975.
10
The effect of BCG-vaccination on vaccinia virus infections in mice.卡介苗接种对小鼠痘苗病毒感染的影响。
Experientia. 1979 Nov 15;35(11):1514-5. doi: 10.1007/BF01962818.

本文引用的文献

1
Lack of detectable circulating interferon in mice protected against vaccinia virus by induction and elicitation with bacterial systems.用细菌系统诱导和激发可使小鼠免受天花病毒感染，而循环干扰素则无法检测到。
Infect Immun. 1973 Jan;7(1):117-8. doi: 10.1128/iai.7.1.117-118.1973.
2
Immunologically Induced and Elicited Local Resistance to Staphylococcus aureus.免疫诱导和引发的金黄色葡萄球菌局部抗性。
Infect Immun. 1970 Dec;2(6):757-61. doi: 10.1128/iai.2.6.757-761.1970.
3
THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.获得性细胞抗性的免疫学基础。
J Exp Med. 1964 Jul 1;120(1):105-20. doi: 10.1084/jem.120.1.105.
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ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES.病毒疾病的发病机制方面
Bacteriol Rev. 1964 Mar;28(1):30-71. doi: 10.1128/br.28.1.30-71.1964.
5
INHIBITION OF THE PRIMARY VACCINIAL LESION AND OF DELAYED HYPERSENSITIVITY BY AN ANTIMONONUCLEAR CELL SERUM.一种抗单核细胞血清对原发性牛痘损伤及迟发型超敏反应的抑制作用
J Infect Dis. 1963 Jul-Aug;113:15-21. doi: 10.1093/infdis/113.1.15.
6
A study on toxic effect of vaccinia virus in mice with special reference to hematological changes.
J Immunol. 1962 Feb;88:184-90.
7
Effect of a primary tuberculous infection on the resistance of male and female mice to Ectromelia.原发性结核感染对雄性和雌性小鼠抗痘苗病毒能力的影响。
Nature. 1960 Aug 20;187:703-4. doi: 10.1038/187703b0.
8
Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice.通过抑制痘苗病毒感染小鼠的尾部损伤来评估抗病毒化合物。
Antimicrob Agents Chemother (Bethesda). 1966;6:536-9.
9
Delayed-type hypersensitivity to Staphylococcus aureus in human subjects.人类受试者对金黄色葡萄球菌的迟发型超敏反应。
J Reticuloendothel Soc. 1970 Nov;8(5):493-8.
10
Cellular immunity in host resistance to viral infections.宿主对病毒感染的细胞免疫。
Arch Intern Med. 1970 Jul;126(1):125-34.

通过细菌感染和特定细菌抗原的持续刺激来保护小鼠免受痘苗病毒感染。

Protection of mice against vaccinia virus by bacterial infection and sustained stimulation with specific bacterial antigens.

作者信息

Allen E G, Mudd S

出版信息

Infect Immun. 1973 Jan;7(1):62-7. doi: 10.1128/iai.7.1.62-67.1973.

DOI:10.1128/iai.7.1.62-67.1973
PMID:4632135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422639/
Abstract

In these experiments, mice which have a strong delayed-type hypersensitivity to mycobacteria were found, when elicited with old tuberculin, to be more resistant to intravenous vaccinia virus challenge than controls. This was manifest as protection from killing when large amounts of virus were injected, or as significantly less tail swelling and damage as well as lower titers of infectious virus when a lesser inoculum was used. Preliminary experiments indicate that animals sensitized with Staphylococcus aureus and elicited with phage lysate of staphylococcus are also more resistant to vaccinia infection.

摘要

在这些实验中，发现对分枝杆菌有强烈迟发型超敏反应的小鼠，在用旧结核菌素激发后，比对照小鼠对静脉注射痘苗病毒攻击更具抵抗力。这表现为在注射大量病毒时能免受致死作用，或者在使用较少接种量时，尾部肿胀和损伤明显减轻，以及传染性病毒滴度较低。初步实验表明，用金黄色葡萄球菌致敏并用葡萄球菌噬菌体裂解物激发的动物，对痘苗感染也更具抵抗力。