通过细菌感染和特定细菌抗原的持续刺激来保护小鼠免受痘苗病毒感染。
Protection of mice against vaccinia virus by bacterial infection and sustained stimulation with specific bacterial antigens.
作者信息
Allen E G, Mudd S
出版信息
Infect Immun. 1973 Jan;7(1):62-7. doi: 10.1128/iai.7.1.62-67.1973.
Abstract
In these experiments, mice which have a strong delayed-type hypersensitivity to mycobacteria were found, when elicited with old tuberculin, to be more resistant to intravenous vaccinia virus challenge than controls. This was manifest as protection from killing when large amounts of virus were injected, or as significantly less tail swelling and damage as well as lower titers of infectious virus when a lesser inoculum was used. Preliminary experiments indicate that animals sensitized with Staphylococcus aureus and elicited with phage lysate of staphylococcus are also more resistant to vaccinia infection.
摘要
在这些实验中，发现对分枝杆菌有强烈迟发型超敏反应的小鼠，在用旧结核菌素激发后，比对照小鼠对静脉注射痘苗病毒攻击更具抵抗力。这表现为在注射大量病毒时能免受致死作用，或者在使用较少接种量时，尾部肿胀和损伤明显减轻，以及传染性病毒滴度较低。初步实验表明，用金黄色葡萄球菌致敏并用葡萄球菌噬菌体裂解物激发的动物，对痘苗感染也更具抵抗力。
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本文引用的文献
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