Greco A V, Altomonte L, Ghirlanda G, Rebuzzi A G, Manna R, Bertoli A
Acta Hepatogastroenterol (Stuttg). 1979 Apr;26(2):98-101.
Immunoreactive serum gastrin from portal and peripheral veins was determined in five controls and in five cirrhotic patients with indwelling portal catheters in basal conditions, during and after 30 min arginine infusion, in order to assess whether the human liver is involved in gastrin metabolism. A significant difference was found between portal and peripheral gastrin concentrations in controls at 0, 60 and 90 min; no significant differences were found in cirrhotics. Our findings support the hypothesis of an at least partial breakdown of endogenous gastrin in the human liver.
测定了5名对照者和5名留置门静脉导管的肝硬化患者在基础状态下、精氨酸输注30分钟期间及之后门静脉和外周静脉中免疫反应性血清胃泌素水平，以评估人类肝脏是否参与胃泌素代谢。在0、60和90分钟时，对照者门静脉和外周胃泌素浓度存在显著差异；肝硬化患者中未发现显著差异。我们的研究结果支持人类肝脏中内源性胃泌素至少部分被分解的假说。
