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1
Treatment of severe bacteroides infections with parenteral clindamycin.用胃肠外途径给予克林霉素治疗严重拟杆菌感染。
Can Med Assoc J. 1972 Dec 23;107(12):1177-81.
2
Treatment of Bacteroides infection with clindamycin-2-phosphate.用磷酸克林霉素治疗拟杆菌感染。
Can Med Assoc J. 1974 Nov 2;111(9):945-7, 949.
3
Treatment of anaerobic infections with lincomycin and clindamycin.用林可霉素和克林霉素治疗厌氧菌感染。
N Engl J Med. 1972 Nov 16;287(20):1006-10. doi: 10.1056/NEJM197211162872002.
4
Treatment of Bacteroides fragilis bacteremia with clindamycin.用克林霉素治疗脆弱拟杆菌菌血症。
J Infect Dis. 1973 Oct;128(4):569-71. doi: 10.1093/infdis/128.4.569.
5
[Therapy for severe anaerobic infections with clindamycin (author's transl)].
Jpn J Antibiot. 1977 Jan;30(1):13-21.
6
High-dose tobramycin combined with clindamycin or lincomycin in the treatment of septic peritonitis and intraabdominal sepsis.大剂量妥布霉素联合克林霉素或林可霉素治疗化脓性腹膜炎和腹腔内脓毒症。
Acta Chir Scand. 1981;147(5):339-46.
7
Lincomycins in the treatment of bacteroides infections.林可霉素治疗拟杆菌感染
Br Med J. 1972 Jan 29;1(5795):280-2. doi: 10.1136/bmj.1.5795.280.
8
Bacteroides infections.拟杆菌感染
Ann Surg. 1973 May;177(5):601-6.
9
Parenteral clindamycin therapy for severe anaerobic infections.
Arch Intern Med. 1974 Jul;134(1):78-82.
10
Clindamycin and lincomycin: oral and parenteral therapy.克林霉素和林可霉素：口服及肠胃外给药疗法。
JAMA. 1977 Apr 4;237(14):1482-4.

引用本文的文献

1
Antimicrobial susceptibilities of anaerobic bacteria: recent clinical isolates.厌氧菌的抗菌药敏性：近期临床分离株
Antimicrob Agents Chemother. 1974 Sep;6(3):311-5. doi: 10.1128/AAC.6.3.311.
2
Speed of bactericidal action of penicillin G, ampicillin, and carbenicillin on Bacteroides fragilis.青霉素G、氨苄西林和羧苄西林对脆弱拟杆菌的杀菌作用速度
Antimicrob Agents Chemother. 1974 Sep;6(3):227-31. doi: 10.1128/AAC.6.3.227.
3
Chemotherapy of an experimental Fusobacterium (Sphaerophorus) necrophorum infection in mice.小鼠实验性坏死梭杆菌（具核梭杆菌）感染的化疗
Antimicrob Agents Chemother. 1974 Jun;5(6):658-62. doi: 10.1128/AAC.5.6.658.
4
Prospective, randomized, double-blind comparison of metronidazole and tobramycin with clindamycin and tobramycin in the treatment of intra-abdominal sepsis.甲硝唑与妥布霉素联用和克林霉素与妥布霉素联用治疗腹腔内脓毒症的前瞻性、随机、双盲比较
Ann Surg. 1980 Aug;192(2):213-20. doi: 10.1097/00000658-198008000-00015.
5
Treatment of Bacteroides infection with clindamycin-2-phosphate.用磷酸克林霉素治疗拟杆菌感染。
Can Med Assoc J. 1974 Nov 2;111(9):945-7, 949.
6
Treatment of anaerobic bacterial infections with clindamycin-2-phosphate.用磷酸克林霉素治疗厌氧细菌感染。
Antimicrob Agents Chemother. 1974 Mar;5(3):276-80. doi: 10.1128/AAC.5.3.276.
7
Streptococcus bovis endocarditis.牛链球菌性心内膜炎
Can Med Assoc J. 1974 Oct 5;111(7):678-9, 82.
8
Infectious diseases: annual review of significant publications.传染病：重要出版物年度综述
Postgrad Med J. 1974 Aug;50(586):485-96. doi: 10.1136/pgmj.50.586.485.
9
Clindamycin phosphate in severe infections mainly caused by Bacteroides fragilis: clinical and microbiological evaluation.磷酸克林霉素用于主要由脆弱拟杆菌引起的严重感染：临床及微生物学评估
Infection. 1974;2(2):59-63. doi: 10.1007/BF01642022.
10
Clindamycin plus gentamicin as expectant therapy for presumed mixed infections.克林霉素加庆大霉素作为对疑似混合感染的保守治疗。
Can Med Assoc J. 1976 Dec 18;115(12):1225-9.

本文引用的文献

1
Bacteroides pneumonias. Characteristics of cases with empyema.
Ann Intern Med. 1968 Feb;68(2):308-17. doi: 10.7326/0003-4819-68-2-308.
2
The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro.二氧化碳对脆弱拟杆菌体外某些抗生素敏感性的影响。
J Clin Pathol. 1970 Apr;23(3):254-8. doi: 10.1136/jcp.23.3.254.
3
Bactericidal activity of five antimicrobial agents against Bacteroides fragilis.五种抗菌剂对脆弱拟杆菌的杀菌活性。
J Infect Dis. 1972 Jul;126(1):104-7. doi: 10.1093/infdis/126.1.104.
4
Lincomycins in the treatment of bacteroides infections.林可霉素治疗拟杆菌感染
Br Med J. 1972 Jan 29;1(5795):280-2. doi: 10.1136/bmj.1.5795.280.
5
Bacteroides bacteremia. Experience in a hospital for neoplastic diseases.拟杆菌属菌血症。肿瘤疾病专科医院的经验。
Cancer. 1972 Jan;29(1):245-51. doi: 10.1002/1097-0142(197201)29:1<245::aid-cncr2820290137>3.0.co;2-v.
6
In vitro antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens.从临床标本中分离出的厌氧菌的体外抗菌药敏性。
Antimicrob Agents Chemother. 1972 Feb;1(2):148-58. doi: 10.1128/AAC.1.2.148.
7
The susceptibility of Bacteroides fragilis to 24 antibiotics.脆弱拟杆菌对24种抗生素的敏感性
J Infect Dis. 1972 Mar;125(3):295-9. doi: 10.1093/infdis/125.3.295.
8
A study in vitro of the sensitivity to antibiotics of Bacteroides fragilis.脆弱拟杆菌对抗生素敏感性的体外研究。
J Clin Pathol. 1968 Jul;21(4):432-6. doi: 10.1136/jcp.21.4.432.
9
Clinical and bacteriological studies with clindamycin.克林霉素的临床与细菌学研究。
Br Med J. 1970 Jun 20;2(5711):703-4. doi: 10.1136/bmj.2.5711.703.

用胃肠外途径给予克林霉素治疗严重拟杆菌感染。

Treatment of severe bacteroides infections with parenteral clindamycin.

作者信息

Haldane E V, Van Rooyen C E

出版信息

Can Med Assoc J. 1972 Dec 23;107(12):1177-81.

PMID:4638419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1941080/
Abstract

Clindamycin, by intravenous or intramuscular administration, was used in the treatment of 18 patients seriously ill with infections due to bacteroides organisms. In 17 cases there was a rapid favourable clinical response to treatment. No serious toxic effects were observed. This study appears to confirm previous in vitro evidence that clindamycin is presently the antibiotic of choice for such infections.

摘要

通过静脉或肌肉注射给予克林霉素，用于治疗18例因拟杆菌属微生物感染而病情严重的患者。17例患者对治疗有迅速良好的临床反应。未观察到严重的毒性作用。本研究似乎证实了先前的体外证据，即克林霉素目前是此类感染的首选抗生素。