甲硝唑与妥布霉素联用和克林霉素与妥布霉素联用治疗腹腔内脓毒症的前瞻性、随机、双盲比较
Prospective, randomized, double-blind comparison of metronidazole and tobramycin with clindamycin and tobramycin in the treatment of intra-abdominal sepsis.
作者信息
Smith J A, Skidmore A G, Forward A D, Clarke A M, Sutherland E
出版信息
Ann Surg. 1980 Aug;192(2):213-20. doi: 10.1097/00000658-198008000-00015.
Abstract
In a prospective, double-blind study, clindamycin was compared with metronidazole, each combined with tobramycin and all by the intravenous route in the treatment of intra-abdominal sepsis. Twenty-three patients received clindamycin and 34 patients received 35 courses of metronidazole. Analysis of the clinical responses of patients indicates that the two antibiotic regiments are of equal efficacy in that there was no difference between them in terms of defervescence or duration of infection. Few adverse effects were noted, and all appeared to be of a minor nature.
摘要
在一项前瞻性双盲研究中，将克林霉素与甲硝唑进行比较，二者均与妥布霉素联合使用，全部采用静脉途径治疗腹腔内脓毒症。23例患者接受了克林霉素治疗，34例患者接受了35个疗程的甲硝唑治疗。对患者临床反应的分析表明，两种抗生素方案疗效相当，在退热或感染持续时间方面二者没有差异。观察到的不良反应很少，且似乎都不严重。
相似文献
1
Prospective, randomized, double-blind comparison of metronidazole and tobramycin with clindamycin and tobramycin in the treatment of intra-abdominal sepsis.甲硝唑与妥布霉素联用和克林霉素与妥布霉素联用治疗腹腔内脓毒症的前瞻性、随机、双盲比较
Ann Surg. 1980 Aug;192(2):213-20. doi: 10.1097/00000658-198008000-00015.
2
Meropenem versus tobramycin plus clindamycin for treatment of intraabdominal infections: results of a prospective, randomized, double-blind clinical trial.美罗培南对比妥布霉素加克林霉素治疗腹腔内感染：一项前瞻性、随机、双盲临床试验的结果
Clin Infect Dis. 1995 Sep;21(3):544-50. doi: 10.1093/clinids/21.3.544.
3
Cefoxitin plus tobramycin and clindamycin plus tobramycin. A prospective randomized comparison in the therapy of mixed aerobic/anaerobic infections.
Arch Surg. 1986 Aug;121(8):891-6. doi: 10.1001/archsurg.1986.01400080033005.
4
Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections.美罗培南与克林霉素/妥布霉素治疗腹腔内感染的随机多中心试验结果
Clin Infect Dis. 1997 Feb;24 Suppl 2:S197-206. doi: 10.1093/clinids/24.supplement_2.s197.
5
Metronidazole in the treatment of intra-abdominal sepsis.甲硝唑治疗腹腔内脓毒症
Surgery. 1983 Jan;93(1 Pt 2):217-20.
6
A randomized clinical trial of moxalactam alone versus tobramycin plus clindamycin in abdominal sepsis.莫西拉坦单药与妥布霉素加克林霉素治疗腹部脓毒症的随机临床试验。
Ann Surg. 1983 Jul;198(1):35-41. doi: 10.1097/00000658-198307000-00007.
7
Short-term antibiotherapy for peritonitis: prospective, randomized trial comparing cefotaxime-metronidazole and clindamycin-tobramycin.腹膜炎的短期抗生素治疗：比较头孢噻肟-甲硝唑与克林霉素-妥布霉素的前瞻性随机试验
J Antimicrob Chemother. 1984 Sep;14 Suppl B:213-6. doi: 10.1093/jac/14.suppl_b.213.
8
9
Double-blind comparison of metronidazole plus gentamicin and clindamycin plus gentamicin in intra-abdominal infection.
Surgery. 1983 Jan;93(1 Pt 2):215-6.
10
[Perioperative antibiotic prophylaxis in colon surgery. Metronidazole and tobramycin versus metronidazole alone. A prospective randomized study].[结肠手术围手术期抗生素预防。甲硝唑和妥布霉素与单用甲硝唑的比较。一项前瞻性随机研究]
Schweiz Med Wochenschr. 1983 Mar 19;113(11):392-4.
引用本文的文献
1
Antibiotic regimens for secondary peritonitis of gastrointestinal origin in adults.成人胃肠道源性继发性腹膜炎的抗生素治疗方案
Cochrane Database Syst Rev. 2005 Apr 18;2005(2):CD004539. doi: 10.1002/14651858.CD004539.pub2.
2
Anti-anaerobic antimicrobial agents: cefoxitin, cefotetan, clindamycin, and metronidazole.抗厌氧抗菌药物：头孢西丁、头孢替坦、克林霉素和甲硝唑。
Tex Heart Inst J. 1990;17(2):77-85.
3
Primary and secondary peritonitis: an update.原发性和继发性腹膜炎：最新进展
Eur J Clin Microbiol Infect Dis. 1998 Aug;17(8):542-50. doi: 10.1007/BF01708616.
4
Intravenous metronidazole for treatment of infections involving anaerobic bacteria.静脉注射甲硝唑用于治疗涉及厌氧菌的感染。
Antimicrob Agents Chemother. 1982 Mar;21(3):441-9. doi: 10.1128/AAC.21.3.441.
5
A randomized comparison of cefoxitin with or without amikacin and clindamycin plus amikacin in surgical sepsis.头孢西丁联合或不联合阿米卡星与克林霉素加阿米卡星治疗外科脓毒症的随机对照研究
Ann Surg. 1981 Mar;193(3):318-23. doi: 10.1097/00000658-198103000-00011.
6
Antibiotic trials in intra-abdominal infections. A critical evaluation of study design and outcome reporting.腹腔内感染的抗生素试验。对研究设计和结果报告的批判性评价。
Ann Surg. 1984 Jul;200(1):29-39. doi: 10.1097/00000658-198407000-00005.
7
A randomized clinical trial of moxalactam alone versus tobramycin plus clindamycin in abdominal sepsis.莫西拉坦单药与妥布霉素加克林霉素治疗腹部脓毒症的随机临床试验。
Ann Surg. 1983 Jul;198(1):35-41. doi: 10.1097/00000658-198307000-00007.
8
Effect of anaerobic bacteria on killing of Proteus mirabilis by human polymorphonuclear leukocytes.厌氧菌对人多形核白细胞杀灭奇异变形杆菌的影响。
Infect Immun. 1983 Jun;40(3):930-5. doi: 10.1128/iai.40.3.930-935.1983.
9
Cephalosporins in surgery. Prophylaxis and therapy.外科手术中的头孢菌素。预防与治疗。
Drugs. 1987;34 Suppl 2:216-39. doi: 10.2165/00003495-198700342-00016.
10
Role of aminoglycoside antibiotics in the treatment of intra-abdominal infection.氨基糖苷类抗生素在腹腔内感染治疗中的作用。
Antimicrob Agents Chemother. 1987 Apr;31(4):485-91. doi: 10.1128/AAC.31.4.485.
本文引用的文献
1
THE BACTERIAL FLORA OF ACUTE PERFORATED APPENDICITIS WITH PERITONITIS: A BACTERIOLOGIC STUDY BASED UPON ONE HUNDRED CASES.急性穿孔性阑尾炎伴腹膜炎的细菌菌群：一项基于100例病例的细菌学研究。
Ann Surg. 1938 Apr;107(4):517-28. doi: 10.1097/00000658-193804000-00006.
2
Antimicrobial susceptibilities of anaerobic bacteria: recent clinical isolates.厌氧菌的抗菌药敏性：近期临床分离株
Antimicrob Agents Chemother. 1974 Sep;6(3):311-5. doi: 10.1128/AAC.6.3.311.
3
Bactericidal activity of five antimicrobial agents against Bacteroides fragilis.五种抗菌剂对脆弱拟杆菌的杀菌活性。
J Infect Dis. 1972 Jul;126(1):104-7. doi: 10.1093/infdis/126.1.104.
4
Clinical importance of infections due to Bacteroides fragilis and role of antibiotic therapy.脆弱拟杆菌感染的临床重要性及抗生素治疗的作用。
Br Med J. 1974 Jul 27;3(5925):225-8. doi: 10.1136/bmj.3.5925.225.
5
Bactericidal activity of metronidazole against Bacteroides fragilis.甲硝唑对脆弱拟杆菌的杀菌活性。
J Clin Pathol. 1973 Jun;26(6):393-5. doi: 10.1136/jcp.26.6.393.
6
Treatment of severe bacteroides infections with parenteral clindamycin.用胃肠外途径给予克林霉素治疗严重拟杆菌感染。
Can Med Assoc J. 1972 Dec 23;107(12):1177-81.
7
The bacteriology of intra-abdominal infections.腹腔内感染的细菌学
Arch Surg. 1974 Sep;109(3):398-9. doi: 10.1001/archsurg.1974.01360030050013.
8
Antimicrobial therapy of experimental intraabdominal sepsis.
J Infect Dis. 1975 Sep;132(3):282-6. doi: 10.1093/infdis/132.3.282.
9
Anaerobic specimen transport device.厌氧标本运送装置。
J Clin Microbiol. 1975 Nov;2(5):441-7. doi: 10.1128/jcm.2.5.441-447.1975.
10
Metronidazole and anaerobic sepsis.甲硝唑与厌氧性败血症
Br Med J. 1976 Dec 11;2(6049):1418-21. doi: 10.1136/bmj.2.6049.1418.
Zotero 插件