合成肽在动物外分泌性胰腺功能不全诊断中的应用
Synthetic peptides in the diagnosis of exocrine pancreatic insufficiency in animals.
作者信息
Imondi A R, Stradley R P, Wolgemuth R
出版信息
Gut. 1972 Sep;13(9):726-31. doi: 10.1136/gut.13.9.726.
Abstract
A new approach in the diagnosis of exocrine pancreatic insufficiency has been evaluated in animals. The method involves the oral administration of a chymotrypsin-labile peptide which contains p-aminobenzoic acid (PABA) as a tracer group. In the small bowel in the presence of chymotrypsin, the PABA is split from the peptide and is rapidly absorbed. The amount of PABA (as total aromatic amines) recovered in the urine during the six hours after the dose is used as an index of exocrine pancreatic function. The procedure has been shown to be reliable in detecting surgically induced pancreatic insufficiency in rats, swine, and dogs.
摘要
一种诊断外分泌性胰腺功能不全的新方法已在动物身上进行了评估。该方法包括口服一种含有对氨基苯甲酸（PABA）作为示踪基团的糜蛋白酶不稳定肽。在小肠中，在糜蛋白酶存在的情况下，PABA从肽中裂解出来并迅速被吸收。给药后6小时内尿中回收的PABA量（以总芳香胺计）用作外分泌胰腺功能的指标。该方法已被证明在检测大鼠、猪和狗手术诱导的胰腺功能不全方面是可靠的。
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