婴幼儿外分泌胰腺功能的对氨基苯甲酸筛查试验
PABA screening test for exocrine pancreatic function in infants and children.
作者信息
Sacher M, Kobsa A, Shmerling D H
出版信息
Arch Dis Child. 1978 Aug;53(8):639-41. doi: 10.1136/adc.53.8.639.
Abstract
P-Amino-benzoic acid (PABA) is split specifically by pancreatic chymotrypsin from the synthetic tripeptide N-benzoyl-L-tyrosyl-PABA. The urinary excretion of absorbed PABA serves as an index for exocrine pancreatic function. The peptide (0.015 g/kg) was administered orally to 20 controls (aged between 5 months and 16 years), 6 patients with exocrine pancreatic insufficiency caused by cystic fibrosis (CF), and 9 newborn infants. In the controls the mean 6-hour PABA recovery was 58.5% (+/- 11.2 SD). Recovery in patients with CF was lower (P less than 0.001) with no overlap. In newborn infants the mean 6-hour PABA recovery was 23.4 (+/- 17.7 SD); overlapping in 3 instances with the results in CF patients. This simple, noninvasive test thus appears promising and merits further investigation in younger infants, especially newborns.
摘要
对氨基苯甲酸（PABA）可被胰凝乳蛋白酶从合成三肽N-苯甲酰-L-酪氨酰-PABA中特异性裂解。吸收后的PABA经尿液排泄可作为胰腺外分泌功能的一项指标。将该肽（0.015 g/kg）口服给予20名对照者（年龄在5个月至16岁之间）、6名由囊性纤维化（CF）导致胰腺外分泌功能不全的患者以及9名新生儿。在对照者中，6小时PABA的平均回收率为58.5%（±11.2标准差）。CF患者的回收率较低（P<0.001），且无重叠。新生儿6小时PABA的平均回收率为23.4（±17.7标准差）；有3例结果与CF患者的结果重叠。因此，这项简单的非侵入性检测似乎很有前景，值得在更小的婴儿尤其是新生儿中进一步研究。
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本文引用的文献
1
THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN.犬和人对取代马尿酸衍生物及其他芳香酸的肾清除率
J Clin Invest. 1945 May;24(3):388-404. doi: 10.1172/JCI101618.
2
Quantitative assessment of exocrine pancreatic function in infants and children.婴幼儿和儿童胰腺外分泌功能的定量评估。
J Pediatr. 1968 Jul;73(1):39-50. doi: 10.1016/s0022-3476(68)80037-x.
3
Synthetic peptides in the diagnosis of exocrine pancreatic insufficiency in animals.合成肽在动物外分泌性胰腺功能不全诊断中的应用
Gut. 1972 Sep;13(9):726-31. doi: 10.1136/gut.13.9.726.
4
Oral administration of a chymotrypsin-labile peptide--a new test of exocrine pancreatic function in man (PFT).口服一种对胰凝乳蛋白酶敏感的肽——一项用于检测人体外分泌胰腺功能的新测试（胰腺功能测试）
Gut. 1976 Jan;17(1):27-32. doi: 10.1136/gut.17.1.27.
5
Exocrine pancreatic function in protein-deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test.
Gastroenterology. 1975 Mar;68(3):488-94.
6
Diagnosis of pancreatic disease by a synthetic peptide. A new test of exocrine pancreatic function.
Lancet. 1976 Mar 27;1(7961):663-6. doi: 10.1016/s0140-6736(76)92777-x.
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