Manabe T, Yokota T, Tobe T
Jpn J Surg. 1982;12(3):178-83. doi: 10.1007/BF02469584.
The assessment of exocrine pancreatic function by the oral administration of a chymotrypsin labile peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BT-PABA) has proved to be an easy and reliable test of exocrine pancreatic function. It has the additional advantage that it can be used to study exocrine pancreatic function in all operative cases, even after gastrointestinal reconstruction. The recovery of p-aminobenzoic acid (PABA) correlates significantly with parameters of the PZ/CCK secretin (PS) test. Following Billroth II gastrectomy, the recovery of PABA decreased to 39.8 +/- 3.2% two weeks after and to 45.4 +/- 4.5% one to two months after operation, significantly lower than the 80.6 +/- 3.4% in normal subjects. In cases of cancer of the head of the pancreas, the exocrine function was 44.0 +/- 3.7%, and decreased to 17.5 +/- 3.0% after total pancreatectomy. Thus, BT-PABA enables a pertinent evaluation of pancreatic function in postoperative patients with various types of gastrointestinal reconstruction and also in cases when the PS test cannot be feasibly used.
通过口服一种对胰凝乳蛋白酶不稳定的肽——N-苯甲酰-L-酪氨酰-对氨基苯甲酸（BT-PABA）来评估胰腺外分泌功能，已被证明是一种简单且可靠的胰腺外分泌功能检测方法。它还有一个额外的优点，即它可用于研究所有手术病例的胰腺外分泌功能，即使是在胃肠道重建术后。对氨基苯甲酸（PABA）的回收率与胰泌素/胆囊收缩素（PS）试验的参数显著相关。毕Ⅱ式胃切除术后，术后两周PABA的回收率降至39.8±3.2%，术后一至两个月降至45.4±4.5%，显著低于正常受试者的80.6±3.4%。在胰头癌病例中，外分泌功能为44.0±3.7%，全胰切除术后降至17.5±3.0%。因此，BT-PABA能够对各种类型胃肠道重建术后的患者以及无法切实使用PS试验的病例的胰腺功能进行恰当评估。
