Kootsey J M, Johnson E A
Biophys J. 1972 Nov;12(11):1496-508. doi: 10.1016/S0006-3495(72)86177-0.
A theoretical model is presented for the early currents in the voltage clamp of cardiac muscle using the single sucrose gap technique. The preparation is represented by a single one-dimensional active cable with modified Hodgkin-Huxley membrane and the interent imperfections in the technique are also included, e.g., leakage through the sucrose gap and resistance in series with the membrane in the test compartment. The stability of the control system was found to depend on the position of the control point with respect to the sucrose gap border. Computed currents for a stable system closely resembled those in the literature and those from a near-ideal system (e.g., squid axon.) The potential immediately across the membrane, however (not including potential drops across the series resistance external to the membrane), was found to be essentially uncontrolled and the "current-voltage" relationship was shown to be almost independent of membrane properties.
利用单蔗糖间隙技术，提出了一种用于心肌电压钳早期电流的理论模型。该标本由具有修正霍奇金-赫胥黎膜的单一一维有源电缆表示，并且还包括该技术中存在的内部缺陷，例如通过蔗糖间隙的泄漏以及测试隔室中与膜串联的电阻。发现控制系统的稳定性取决于控制点相对于蔗糖间隙边界的位置。稳定系统的计算电流与文献中的电流以及来自近乎理想系统（例如鱿鱼轴突）的电流非常相似。然而，紧挨着膜的电位（不包括膜外部串联电阻上的电位降）被发现基本上不受控制，并且“电流-电压”关系被证明几乎与膜特性无关。
