咪康唑和十二烷基咪唑对玉米黑粉菌中甾醇生物合成的影响。
Effects of miconazole and dodecylimidazole on sterol biosynthesis in Ustilago maydis.
作者信息
Henry M J, Sisler H D
出版信息
Antimicrob Agents Chemother. 1979 Apr;15(4):603-7. doi: 10.1128/AAC.15.4.603.
Abstract
Miconazole at minimal fungitoxic concentrations inhibits ergosterol biosynthesis in sporidia of Ustilago maydis by interference with sterol C14 demethylation. The action is analogous to that of the fungicides triarimol and fenarimol. The fungicide 1-dodecylimidazole at low concentrations (0.1 to 0.25 mug/ml) inhibits sterol C14 demethylation; however, at higher concentrations (1.0 mug/ml or greater) it also inhibits 2,3-oxidosqualene cyclization and subsequent transmethylation. It is postulated that this diversity of effects of 1-dodecylimidazole results from binding of the inhibitor to sterol carrier protein(s).
摘要
最低抑菌浓度的咪康唑通过干扰甾醇C14去甲基化来抑制玉米黑粉菌担孢子中的麦角甾醇生物合成。其作用类似于杀菌剂三唑醇和氯苯嘧啶醇。低浓度（0.1至0.25微克/毫升）的杀菌剂1-十二烷基咪唑可抑制甾醇C14去甲基化；然而，在较高浓度（1.0微克/毫升或更高）时，它也会抑制2,3-氧化角鲨烯环化及随后的甲基转移。据推测，1-十二烷基咪唑这种多样的作用效果是由于抑制剂与甾醇载体蛋白结合所致。
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