Seppälä M, Ruoslahti E
Br Med J. 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769.
The clinical value of maternal serum alpha-fetoprotein (AFP) as a guide to the outcome of threatened abortion was assessed. After the thirteenth week of gestation, abortion occurred more frequently (10/12) in women with abnormal serum AFP levels than in those (2/12) whose AFP concentrations were within the normal range. Low levels were present in women with blighted ovum and high concentrations were associated with intrauterine fetal death. In legal first and second trimester abortions, the circulating maternal AFP levels in postabortion samples were often higher than before abortion, irrespective of whether abortion was performed instrumentally or induced with prostaglandins. Maternal serum AFP levels provide a new means for prediction of the outcome of threatened abortion.
评估了孕妇血清甲胎蛋白（AFP）作为先兆流产结局指标的临床价值。妊娠13周后，血清AFP水平异常的孕妇流产发生率更高（10/12），高于AFP浓度在正常范围内的孕妇（2/12）。空卵妊娠妇女的AFP水平较低，而高浓度与宫内胎儿死亡有关。在合法的孕早期和孕中期人工流产中，无论流产是通过器械操作还是使用前列腺素诱导，流产后样本中母体循环AFP水平通常高于流产前。孕妇血清AFP水平为预测先兆流产结局提供了一种新方法。
