Margni R A, Hajos S, Manghi M, Perdigón G, Leoni J
Immunology. 1974 Nov;27(5):863-70.
A study has been made of the fixation to sheep, rabbit, guniea-pig and human red cells (both untreated and trypsin-treated cells) brought about by different non-precipitating antibodies and their corresponding F(ab′) fragments, as well as by human IgG and its corresponding fragments F(ab′), Fab and Fc. The results obtained with the antiglobulin test seem to indicate that there exists on the surface of the red cells Fc receptors which exhibit a greater affinity for the Fc fragment which has undergone structural changes consequent upon either the immunoglobulin-binding interaction or as a result of enzymic degradation. The Fc receptors would appear to be superficial in the majority of animal species studied. In the case of human red cells their liberation depends upon prior treatment with trypsin On the basis of these investigations consideration should be given to the theory that the passive haemagglutination mediated by non-precipitating antibodies could be of the mixed type, with the participation of both Fab and Fc fragments.
已经对不同的非沉淀抗体及其相应的F(ab′)片段，以及人IgG及其相应的片段F(ab′)、Fab和Fc对绵羊、兔、豚鼠和人红细胞（未处理的细胞和经胰蛋白酶处理的细胞）的固定作用进行了研究。抗球蛋白试验获得的结果似乎表明，红细胞表面存在Fc受体，这些受体对因免疫球蛋白结合相互作用或酶促降解而发生结构变化的Fc片段表现出更高的亲和力。在所研究的大多数动物物种中，Fc受体似乎位于细胞表面。就人红细胞而言，其释放取决于预先用胰蛋白酶处理。基于这些研究，应考虑非沉淀抗体介导的被动血凝反应可能是混合型的这一理论，即Fab和Fc片段均参与其中。
