伴刀豆球蛋白A刺激的淋巴细胞产生促有丝分裂因子。
Production of mitogenic factor by concanavalin A stimulated lymphocytes.
作者信息
Smith J L, Barker C R
出版信息
Clin Exp Immunol. 1972 Dec;12(4):507-14.
Abstract
Human lymphocytes stimulated into mitosis by the non-specific mitogen Concanavalin A (Con A) produce a factor stimulating fresh lymphocytes. Sephadex G-50 treatment was used successfully to remove residual Con A activity from the culture supernatants. The time courses of the responses of both autologous and allogeneic lymphocytes to the factor were similar. All normal lymphocyte preparations tested responded to factor whilst the cells of one of four patients with chronic lymphocytic leukaemia did not respond.
摘要
被非特异性促有丝分裂原刀豆球蛋白A（Con A）刺激进入有丝分裂的人淋巴细胞会产生一种刺激新鲜淋巴细胞的因子。使用葡聚糖凝胶G - 50处理成功地从培养上清液中去除了残留的Con A活性。自体淋巴细胞和同种异体淋巴细胞对该因子的反应时间进程相似。所有测试的正常淋巴细胞制剂都对该因子有反应，而四名慢性淋巴细胞白血病患者中的一名患者的细胞没有反应。
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