Morris R J, Guggenheim S J, McIntosh R M, Rubin R L, Kohler P F
Arthritis Rheum. 1979 Aug;22(8):864-70. doi: 10.1002/art.1780220809.
Thirty-two biopsies of kidneys and of normal skin were performed simultaneously on patients with systemic lupus erythematosus (SLE) to determine whether the deposition of immune reactants in skin was correlated with the severity of renal injury or with several serologic measures of systemic disease activity. Immunofluorescent deposits at the dermal-epidermal junction (lupus band test) did not correlate with any clinical or histologic measures of glomerulonephritis or with serologic abnormalities. Immune deposits in dermal venules were found in 56% of the skin biopsies and were correlated with hypocomplementemia and higher levels of immune complexes in serum, and possibly with glomerular subendothelial electron dense deposits. Azathioprine therapy was correlated with absence of both sub-epidermal and vascular immune deposits. Immuno-fluorescent findings on serial skin biopsies on 13 patients were highly inconsistent. It is concluded that the lupus band test is clinically useful only as a diagnostic aid but not helpful in assessing renal or serologic activity of lupus, and that dermal vascular deposits of immunoglobulin or complement are more frequent than previoulsy recognized and correlate with measures of circulating immune complexes.
对系统性红斑狼疮（SLE）患者同时进行了32次肾脏活检和正常皮肤活检，以确定皮肤中免疫反应物的沉积是否与肾损伤的严重程度或系统性疾病活动的几种血清学指标相关。真皮-表皮交界处的免疫荧光沉积（狼疮带试验）与肾小球肾炎的任何临床或组织学指标或血清学异常均无相关性。在56%的皮肤活检中发现真皮小静脉中有免疫沉积物，且与低补体血症和血清中较高水平的免疫复合物相关，可能还与肾小球内皮下电子致密沉积物相关。硫唑嘌呤治疗与表皮下和血管免疫沉积物的缺失相关。对13例患者进行的系列皮肤活检的免疫荧光结果高度不一致。得出的结论是，狼疮带试验在临床上仅作为一种诊断辅助手段有用，而无助于评估狼疮的肾脏或血清学活动，并且免疫球蛋白或补体的真皮血管沉积物比以前认识到的更为常见，且与循环免疫复合物的指标相关。
